DEVELOPMENT OF OLMESARTAN MEDOXOMIL-LOADED CHITOSAN MICROPARTICLES: A POTENTIAL STRATEGY TO IMPROVE PHYSICOCHEMICAL AND MICROMERITIC PROPERTIES
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 8
Abstract
Objective: The objective of the present research was to improve physicochemical and micromeritic properties of Olmesartan Medoxomil (OLM), BCS class II antihypertensive drug by loading in Chitosan (CH) microparticles.Methods: The 32 full factorial design was assigned for microparticles prepared by single emulsion technique method using CH, a natural polymer and Glutaraldehyde (GA) as cross linking agent. Developed microparticles were characterized for Micromeritic properties, morphology by Scanning Electron Microscopy (SEM), drug entrapment efficiency, in vitro drug release, and interaction studies Fourier transfer infrared spectroscopy (FTIR) & Differential Scanning Calorimetry (DSC), drug crystallinity study by X-ray diffractometry (XRD) & DSC.Results: Maximum entrapment efficiency was found 61.76% for maximal CH and lower GA concentration. Saturation solubility of microparticles was increased by 13.74 times to that of pure OLM. FTIR showed compatibility between drug and polymer. XRD, DSC and SEM studies confirmed reduction in crystallinity of drug. It led to increase in dissolution profile of the drug and showed 92.61% of drug release in 120 min. These microparticle preparations also helped in improving micromeritic properties like bulk density, tapped density, the angle of repose, Hausner’s ratio and Carr’s index.Conclusion: The results obtained in the present work demonstrate the potential use of CH to modulate physicochemical and micromeritic properties of OLM especially obtaining significant improvement in dissolution rate. Â
Authors and Affiliations
Gurav A. S. , Sayyad F. J. , Gavhane Y. N. , Khakal N. N
Keywords
Related Articles
- EP ID EP578348
- DOI -
- Views 52
- Downloads 0
SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL STUDY OF SOME BENZENESULFONAMIDE BASED BIPYRAZOLES
Objectives: To synthesize, characterize and evaluate antimicrobial properties of some benzenesulfonamide based bipyrazole.Methods: The benzenesulfonamide based bipyrazole 1a-d & 2a-f have been synthesized by the reac...
NEUROPROTECTIVE ACTIVITY OF NOVEL CUR-CA-THIONE AND ITS OXIDATIVE STRESS STUDY
Objective: Alzheimer’s disease a progressive neurodegenerative disorder affected by the formation of amyloid beta and tau proteins. Medicinal plants have been proved significantly for its anti-oxidant and anti-inflamma...
THERAPEUTIC ADVANCEMENTS IN MANAGEMENT OF IRON OVERLOAD–A REVIEW
Removal of excess of free iron, produced under certain physiological conditions in human body, has always been of great concern for therapists worldwide. A number of naturally occurring and synthetic ligands are being ex...
PHOSPHATE SOLUBILIZING MICROBES: AN EFFECTIVE AND ALTERNATIVE APPROACH AS BIOFERTILIZERS
It is undoubtedly clear that phosphorus is the second most important nutrient after nitrogen required for growth of plants. It is an essential element in all living systems. Hardly 1%-2% of phosphorous is supplied to oth...
DOCKING STUDY OF METHYL HESPERIDIN AS NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR
Objective: This study aims to analyze the methyl hesperidin physicochemical properties related to solubility and permeability, and the affinity of methyl hesperidin against reverse transcriptase HIV-1 activity as a compe...