Development of validated liquid chromatographic method for estimation of levocetirizine from pharmaceutical dosage forms
Journal Title: Journal of Applied Pharmaceutical Science - Year 2011, Vol 1, Issue 10
Abstract
A simple and rapid high-performance liquid chromatographic (HPLC) method for the determination levocetirizine has been developed. The chromatographic system consisted of a Water 2695 binary gradient pump, Water 2487 dual wavelength absorbance detector, and Empower 2 software. Separation was achieved on the XTerra symmetry C18 column at room temperature. The sample was introduced through an injector valve with a 20 μL sample loop. The results obtained showed a good agreement with the declared content. Recovery values of levocetirizine in tablets were from 99.57-100.48 %. The proposed method is rapid, accurate and selective; it may be used for the quantitative analysis of levocetirizine from raw materials, in bulk drugs and other dosage formulations.
Authors and Affiliations
Chaitanya Prasad MK, Vidyasagar G, Sambasiva Rao KRS, Madhusudhanareddy Induri, Ramanjeneyulu S
Keywords
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- EP ID EP98077
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Development of validated liquid chromatographic method for estimation of levocetirizine from pharmaceutical dosage forms
A simple and rapid high-performance liquid chromatographic (HPLC) method for the determination levocetirizine has been developed. The chromatographic system consisted of a Water 2695 binary gradient pump, Water 2487 du...