Diagnostic accuracy of squash cytology and role of GFAP immunoexpression in glial tumors
Journal Title: Indian Journal of Pathology and Oncology - Year 2018, Vol 5, Issue 1
Abstract
Introduction Intraoperative squash technique provides rapid and reliable diagnosis which is helpful to monitor or modify the treatment approach We carried out the present study to compare the accuracy of squash preparation with histopathological diagnosis and also to study the role of GFAP immunostaining in gliomasMaterial and Methods Clinicoradiologically diagnosed 127 cases of gliomas were subjected to both squash smear cytology and histopathological examination also to GFAP staining using monoclonal antibody EP672Y clone Taking histopathology as gold standard diagnostic accuracy and statistical values were calculated Immunohistochemical analysis was compared with final diagnosisResults Overall diagnostic accuracy of squash cytology was observed as 952 sensitivity991 PPV 991 All low grade astrocytomas and ependymoma showed strong diffuse positivity while high grade astrocytomas were focally reactive Negative immunoexpression was seen in case of oligodendroglioma and pituitary adenomaConclusion Squash cytology is of great value in rapid intraoperative consultation of gliomas GFAP can be used as an adjunctive tool to verify the astroglial differentiation especially in diagnostically difficult casesKeywords diagnostic accuracy GFAP Gliomas Squash
Authors and Affiliations
Sanjeev Kishore, Brijesh Thakur, Aparna Bhardwaj, Anuradha Kusum
Keywords
Related Articles
- EP ID EP473174
- DOI 10.18231/2394-6792.2018.0003
- Views 64
- Downloads 0
Role of mast cells in surgically resected specimens of appendices
Introduction Mast cells are very closely linked to diseases and have a significant role in inflammatory process The functions of mast cells depends on release of preformed granules The aims and objectives of present stud...
Comparative study of platelet indices in coronary artery diseases
Introduction With urbanization and increase in sedentary lifestyle prevalence of CAD Coronary artery disease is looming large as the new epidemic afflicting Indians Altered platelet morphology and functions have been lin...
Prospective study of apoptotic index and mitotic index as a predictor of response to radiation in subjects of squamous cell carcinoma of uterine cervix treated by radical radiotherapy
Introduction There exists a wide variation in the response of tumors to radiotherapy and prognosis from individual to individual after radiotherapy to carcinoma of uterine cervix in all stages Before embarking on treatme...
Small cell osteosarcoma of the maxilla
Osteosarcoma (OS), a primary malignant bone tumor usually arises from the metaphyses of long bones and less commonly in the flat bones. Small cell osteosarcoma (SCO) is a rare variant, comprising 1.5% of all OSs. A 37 ye...
Diagnostic utility of haematological parameters and C-reactive protein in early detection of neonatal septicaemia in developing countries
Introduction Septicaemia is one of the major causes of mortality and morbidity during the neonatal period especially in developing countries Early diagnosis of neonatal sepsis is a diagnostic problem due to nonspecific c...