Diagnostic accuracy of squash cytology and role of GFAP immunoexpression in glial tumors
Journal Title: Indian Journal of Pathology and Oncology - Year 2018, Vol 5, Issue 1
Abstract
Introduction Intraoperative squash technique provides rapid and reliable diagnosis which is helpful to monitor or modify the treatment approach We carried out the present study to compare the accuracy of squash preparation with histopathological diagnosis and also to study the role of GFAP immunostaining in gliomasMaterial and Methods Clinicoradiologically diagnosed 127 cases of gliomas were subjected to both squash smear cytology and histopathological examination also to GFAP staining using monoclonal antibody EP672Y clone Taking histopathology as gold standard diagnostic accuracy and statistical values were calculated Immunohistochemical analysis was compared with final diagnosisResults Overall diagnostic accuracy of squash cytology was observed as 952 sensitivity991 PPV 991 All low grade astrocytomas and ependymoma showed strong diffuse positivity while high grade astrocytomas were focally reactive Negative immunoexpression was seen in case of oligodendroglioma and pituitary adenomaConclusion Squash cytology is of great value in rapid intraoperative consultation of gliomas GFAP can be used as an adjunctive tool to verify the astroglial differentiation especially in diagnostically difficult casesKeywords diagnostic accuracy GFAP Gliomas Squash
Authors and Affiliations
Sanjeev Kishore, Brijesh Thakur, Aparna Bhardwaj, Anuradha Kusum
Diagnostic accuracy of squash cytology and role of GFAP immunoexpression in glial tumors
Introduction Intraoperative squash technique provides rapid and reliable diagnosis which is helpful to monitor or modify the treatment approach We carried out the present study to compare the accuracy of squash preparati...
Testicular touch imprint: reinforcing its role in male infertility
Introduction: Testicular biopsy plays an important role in the evaluation of male infertility. In the present decade of Mapping of testis for foci of spermatogenesis and testicular sperm extraction for the treatment of i...
A retrospective cross sectional analysis of histopathological distribution of breast cancer according to age at a tertiary care teaching hospital
Introduction As per the WHO there were 519000 women who died in the year 2004 and 69 of the worlds cancer deaths are due to breast cancer The present study was conducted with the aim to determine the histological variant...
Study to identify the role of high performance liquid chromatography in detecting haemoglobinopathies in antenatal patients
Introduction Haemoglobinopathy is a major genetic public health problems in India responsible for significant morbidity and mortality Individuals with trait carriers are healthy and unaware of their carrier status unless...
Cervical Cytopathology in women attending rural area at Tertiary Care Hospital
Aims and Objectives: Cervical cancer has always been a growing concern in developing countries like India. Prevent ability at pre malignant/pre invasive stages has yearned the need for studying screening methods in detai...