Diagnostic accuracy of squash cytology and role of GFAP immunoexpression in glial tumors

Journal Title: Indian Journal of Pathology and Oncology - Year 2018, Vol 5, Issue 1

Abstract

Introduction Intraoperative squash technique provides rapid and reliable diagnosis which is helpful to monitor or modify the treatment approach We carried out the present study to compare the accuracy of squash preparation with histopathological diagnosis and also to study the role of GFAP immunostaining in gliomasMaterial and Methods Clinicoradiologically diagnosed 127 cases of gliomas were subjected to both squash smear cytology and histopathological examination also to GFAP staining using monoclonal antibody EP672Y clone Taking histopathology as gold standard diagnostic accuracy and statistical values were calculated Immunohistochemical analysis was compared with final diagnosisResults Overall diagnostic accuracy of squash cytology was observed as 952 sensitivity991 PPV 991 All low grade astrocytomas and ependymoma showed strong diffuse positivity while high grade astrocytomas were focally reactive Negative immunoexpression was seen in case of oligodendroglioma and pituitary adenomaConclusion Squash cytology is of great value in rapid intraoperative consultation of gliomas GFAP can be used as an adjunctive tool to verify the astroglial differentiation especially in diagnostically difficult casesKeywords diagnostic accuracy GFAP Gliomas Squash

Authors and Affiliations

Sanjeev Kishore, Brijesh Thakur, Aparna Bhardwaj, Anuradha Kusum

Keywords

Related Articles

Determinants of blood donation in undergraduate Medical Students in Uttar Pradesh, India

Introduction: Advances in healthcare require adequate quantities of safe blood, which can be obtained by regular voluntary blood donation. The college-going students constitute a healthy pool of potential donors. This st...

Study of p53 gene over expression as a prognostic marker in squamous cell carcinoma of the oral cavity

The present study entitled Study of p53 gene expression as a prognostic marker in squamous cell carcinoma of oral cavity was conducted in the department of pathology SRMSIMS Bareilly 66 cases diagnosed on histopathology...

Analysis of metastatic bone disease in a tertiary care centre

Introduction Metastasis to the bone is the third commonest site next to lung and liver It is one of the leading cause of morbidity and mortality in the world being an important prognostic indicator in advanced cancers Th...

Frozen section as a guide in intra operative decision making in management of adnexal mass lesions

Ovarian tumours present with vague pelvic abdominal and menstrual symptoms Lack of histological diagnosis before hand with no definite evidence of malignancy intra operatively may put the surgeon at the cross roads wheth...

Spectrum of Endometrial lesions in patients presenting with abnormal uterine bleeding

Introduction Most of the patients with bleeding per vaginum undergo either colposcopic evaluation or Pap smear for cervical pathology or Trans Vaginal Ultrasound and endometrial biopsy to diagnose the definite pathology...

Download PDF file
  • EP ID EP473174
  • DOI 10.18231/2394-6792.2018.0003
  • Views 61
  • Downloads 0

How To Cite

Sanjeev Kishore, Brijesh Thakur, Aparna Bhardwaj, Anuradha Kusum (2018). Diagnostic accuracy of squash cytology and role of GFAP immunoexpression in glial tumors. Indian Journal of Pathology and Oncology, 5(1), 12-17. https://www.europub.co.uk/articles/-A-473174