Diagnostic and Prognostic Value of Calprotectin (MRP8/MRP14) in the Blood of Patients with Different Types of Juvenile Idiopathic Arthritis
Journal Title: Здоров`я дитини - Year 2016, Vol 7, Issue 75
Abstract
Introduction. Determining the levels of S100A8 proteins (alias: MRP8), S100A9 (alias: MRP14) may contribute to early diagnosis of systemic arthritis in children. The objective of the study was to compare blood levels of calprotectin (MRP8/14 (S100A8/9)) in patients with systemic, polyarticular, RF-negative and oligoarticular types of juvenile idiopathic arthritis (JIA) in the active stage of the disease and to investigate the correlation between blood levels of calprotectin (MRP8/14 (S100A8/9)) with clinical and laboratory markers of JIA activity. Results. It was shown that calprotectin blood level was higher in patients with systemic course of the disease (median 13,800 ng/ml) and was significantly different from that of healthy children (median 1,800 ng/ml, p = 0.00002), indicators of patients with articular forms of JIA (median 2,700 ng/ml, p = 0.000008), patients with polyarthritis and negative RF (median 3,800 ng/ml, p = 0.003226) and oligoarthritis (median 2,500 ng/ml, p = 0.000009). The highest calprotectin levels in the blood were found in patients with newly diagnosed systemic JIA: the median was 32,500 ng/ml (from 13,800 to 177,000 ng/ml). A direct correlation of blood calprotectin was established with the rate of JADAS 27 blood activity (p = 0.000009), erythrocyte sedimentation rate (p = 0.000079) and C-reactive protein (p = 0.000058). Conclusions. Calprotectin level in the blood (MRP8/MRP14) (MRP8/14 (S100A8/9)) is one of the indicators that can be used to confirm the diagnosis of systemic JIA and to monitor the activity and effectiveness of therapy.
Authors and Affiliations
Ya. Ye. Boiko
Keywords
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- EP ID EP182459
- DOI 10.22141/2224-0551.7.75.2016.86719
- Views 102
- Downloads 0
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