DIAGNOSTIC VALUE OF PROCALCITONIN IN COVID-19 DISEASE
Journal Title: International scientific journal Science and Innovation - Year 2023, Vol 2, Issue 4
Abstract
After the onset of the COVID 19 pandemic, there was a need for reliable biomarkers that reflect the rapid progression of the disease to stratify high-risk patients. There is an increased demand for the use of biomarkers that reflect cell and organ damage in the disease of SOVID 19. Plasma biomarkers reflecting bacterial inflammation in the body, including C-reactive protein (CRO) and procalcitonin (PKT) in the diagnosis of bacterial pneumonia, have taken a firm place in the management algorithm of patients with bacterial infection [1,3]. However, since COVID 19 is an understudied disease, further research is needed to develop practical recommendations. It is known that the level of CRP is related to the severity of the course, the spread of inflammatory infiltration, and the prognosis of community-acquired bacterial pneumonia, with its concentration > 100 mg / l, the specificity of confirming bacterial pneumonia reaches 90%, with a concentration < 20 mg / l, the diagnosis is unlikely [1 ,2]. At the beginning of the COVID 19 pandemic, the high level of CRO in the blood of patients is often considered a marker of an infection that is considered to be bacterial, and can be the basis for prescribing antibacterial therapy. Also, high levels of procalcitonin, D-dimer, and ferritin in the blood of patients indicate that a systemic inflammatory reaction is starting in the body. An increase in the level of CRO in the body is related to the severity of the disease and is also one of the main criteria for prescribing anti-inflammatory therapy [2, 4,5]. In addition, it is important to analyze the practical possibilities and prospects of using PKT in bacterial infections - acute pneumonia and infection with the new coronavirus. Procalcitonin is a polypeptide that is normally produced in the cells of the thyroid gland and its concentration in healthy people should not exceed 0.01 ng/ml.
Authors and Affiliations
Ergasheva Munisa Yakubovna, Subxonova Sarvinoz Komilovna
Keywords
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- EP ID EP715773
- DOI 10.5281/zenodo.7875687
- Views 84
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