Diagnostic value of ultrasound combined with serum CCL3 and P-selectin for postoperative lower extremity deep vein thrombosis in patients with hip fractures
Journal Title: Chinese Journal of Clinical Research - Year 2025, Vol 38, Issue 2
Abstract
Objective： To investigate the value of color Doppler ultrasound combined with serum chemokine C-C motif ligand 3(CCL3) and P-selectin levels for the diagnosis of postoperative lower extremity deep vein thrombosis(LEDVT) in patients with hip fractures. Methods： Eighty patients with hip fractures complicated with LEDVT admitted to Xi'an Gaoxin Hospital from September 2022 to September 2024 were regarded as the LEDVT group, 80 patients with hip fractures without LEDVT were regarded as the non-LEDVT group, and 80 healthy individuals who experienced physical examination were regarded as the control group. The levels of serum CCL3 and P-selectin in three groups were compared. Color Doppler flow imaging (CDFI) was applied to measure the inner diameters of the common femoral vein (CFV) and deep femoral vein (DFV), and the subcutaneous tissue thickening was calculated. Multivariate logistic regression was applied to analyze the influencing factors of LEDVT in patients with hip fractures. ROC curve was applied to analyze the diagnostic value of ultrasound combined with serum CCL3 and P-selectin levels for LEDVT in patients with hip fractures. Results： Compared to the control group, both serum CCL3 and P-selectin levels were significantly higher in the LEDVT group (P＜0.05). Compared to the non-LEDVT group, the levels of serum CCL3, P-selectin, CFV, DFV, and subcutaneous tissue thickening were prominently higher in the LEDVT group (P＜0.05). CFV, PFV, subcutaneous tissue thickening, CCL3, and P-selectin were influencing factors for LEDVT in patients with hip fractures (P＜0.05). The combined diagnostic AUC (0.956) was significantly higher than that of any single indicator, with a sensitivity of 81.25% and specificity of 96.25%. Conclusion：The levels of serum CCL3 and P-selectin are obviously upregulated in patients with hip fracture complicated with LEDVT, both of which are influencing factors for the occurrence of LEDVT in patients with hip fracture. Ultrasound combined with serum CCL3 and P-selectin levels has high diagnostic value for LEDVT in patients with hip fractures.
Authors and Affiliations
YUAN Bo, DONG Hongna, LI Yali, YANG Wenbin, RAN Chao
Keywords
Related Articles
- EP ID EP759945
- DOI 10.13429/j.cnki.cjcr.2025.02.013
- Views 34
- Downloads 0
Advances in vasculogenic mimicry in breast cancer
Vasculogenic mimicry (VM) is a blood vessel-like structure formed by tumor cells and extracellular matrix, which can mimic the function of blood vessels while providing nutrients to tumors. Tumor angiogenesis plays an im...
Ultrasound artificial intelligence in the assessment of liver fibrosis
Liver fibrosis is a necessary step in the progression of various chronic liver diseases to cirrhosis and hepatocellular carcinoma, so early diagnosis of liver fibrosis is of great clinical significance. Ultrasound is the...
Efficacy and immunomodulatory effect of anlotinib combined with GP regimen in the treatment of advanced non-small cell lung cancer
<b>Objective</b> To explore the clinical efficacy and immunomodulatory effects of anlotinib capsule combined with GP regimen in the treatment of advanced non-small cell lung cancer(NSCLC). <b>Methods</b> Forty patients w...
Construction and validation of a LASSO regression-based nomogram prediction model for active tuberculosis
Objective To develop and validate a nomogram prediction model for the early diagnosis of active pulmonary tuberculosis (ATB) based on LASSO regression. Methods A total of 403 patients with ATB admitted to the Third Peop...
Efficacy and safety of filiform needle combined with modified Zilan decoction for treatment of verruca plana among adolescents
Objective To evaluate the clinical efficacy and safety of filiform needles combined with modified Zilan decoction in treating verruca plana in adolescents. Methods A total of 120 adolescents with verruca plana treated at...