Diclofenac Induced Fixed Drug Eruption
Journal Title: International Journal of Pharmacological Research - Year 2016, Vol 6, Issue 2
Abstract
Background: Diclofenac is the most commonly used non-steroidal anti-inflammatory drug (NSAID) for treating various inflammatory and painful conditions. It is generally well tolerated; gastric upset is the most common adverse effect. However very few cases of fixed drug eruptions were reported. Here we present a case of Diclofenac Induced Fixed Drug Eruption. A 62 year old male patient developed fixed drug eruptions with plaques on left thigh two days after receiving diclofenac for osteoarthritic pain. Other etiologies including insect bite, infections were ruled out. One week later after stopping the drug, the lesions were subsided. Diclofenac was strongly suspected as the casual drug. CD8+ effector T-cells have shown to play an important role. However it seems to be a reversible and drug related event. Although it is not life-threatening, fixed drug eruption can have significant effect on the quality of life of patients. Conclusion: Diclofenac is one of the most commonly prescribed NSAIDs by the Physicians. It is usually well tolerated, gastric upset is the most common adverse effect noted with this drug. This case is being reported to highlight a drug as safe as Diclofenac may also be associated with Fixed Drug Eruptions.
Authors and Affiliations
Umeshchandra C Honnaddi, Banderao V. Patil, Madhushalini U. Honnaddi, Tharangini S. R, Dr. Sajid
Keywords
Related Articles
- EP ID EP435270
- DOI 10.7439/ijpr.v6i2.2883
- Views 63
- Downloads 0
Synthesis and anticonvulsant activity of certain chalcone based pyrazoline compounds
Convulsions are involuntary, violent, spasmodic and prolonged contractions of skeletal muscles. That means a patient may have epilepsy without convulsions and vice versa. Epilepsy is a common neurological abnormality aff...
A study Antiurolithiatic Activity of ethanolic extract of Asparagus racemosus in animal models
Objective: To investigate the Antiurolithiatic Activity of ethanolic extract of Asparagus racemosus in animal models. Materials and Methods: The study includes performing on healthy albino rats of either sex weighing 22...
Knowledge, Attitude and Practice of Adverse Drug Reactions Reporting Among Healthcare Professionals
Objectives: This study was conducted to evaluate knowledge, attitude and practice of Adverse Drug Reactions (ADR) reporting among Healthcare Professionals. Methods: A cross-sectional study was done by survey using quest...
Effect of menstrual cycle phase on glucose kinetics in healthy women & women with premenstrual symptoms
Objective: To compare the blood glucose levels during the two phases of the menstrual cycle between healthy women and patients with premenstrual syndrome (PMS). Methods: From January of 2012 to the August of 2013, a des...
Phytochemical, trace metals assessment and antimicrobial efficacy of Barleria cristata
Traditional plants contains various secondary metabolites which have shown significant pharmacological activity. In the present paper, we analysed the phytochemical, trace metal and antimicrobial activity of ethanolic le...