Differential and Combined Effects of Simvastatin and Vildagliptin on Angiogenic Markers and Oxidative Stress in Hind Limb Model of Ischemia in Diabetic Rats
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2014, Vol 4, Issue 35
Abstract
Background: This study investigated the potential therapeutic effect of simvastatin and vildagliptin and their combination on angiogenesis in diabetic hind-limb ischemia. Methods: 60 Sprague-dawely rats were divided into 5 groups, group A (normal control), group B (diabetic ischemic control), group C (simvastatin treated diabetic ischemic group), group D (vildagliptin treated diabetic ischemic group) and group E (combined sim. + vild. diabetic ischemic group). Parameters of angiogenesis as well as oxidative stress markers were evaluated. Results: Increased capillary density in ischemic gastrocnemius tissue of diabetic rats treated with either simvastatin or vildagliptin with marked increase in its combination. This effect was accompanied by up-regulated plasma levels of HO-1, nitric oxide, vascular endothelial growth factor (VEGF) and expression of HIF-1 alpha levels. Tissue SOD and Catalase enzymes activities were normalized in groups treated with simvastatin or their combination with vildagliptin with concomitant decrease of lipid peroxidation. Conclusion: Both vildagliptin and simvastatin has antioxidant and angiogenic effects and their combination could be a promising strategy in the management of diabetes associated peripheral arterial disease.
Authors and Affiliations
Amany Shalaby, Heba Kamal
Keywords
Related Articles
- EP ID EP348767
- DOI 10.9734/BJMMR/2014/10804
- Views 99
- Downloads 0
Effect of Admission Hyperglycaemia on Infarct Size and Clinical Outcome in Black Patients with Acute ISCHAEMIC Stroke, Northeast Nigeria
Aims: To determine the relationship between admission blood glucose level, infarct size and stroke outcome in black African patients with acute ischaemic stroke. Study Design: The study was cross-sectional. Place and D...
Predictive Score of Maternal and Foetal Prognosis during Labour in Primiparous Woman in a Congolese Hospital
Background: In Africa, primiparity is associated with high maternal and neonatal morbidity and mortality during pregnancy and childbirth. This study aims to establish a clinical score to identify the primiparous parturie...
Sero-prevalence of Hepatitis B Infection and Its Risk Factors among Women Admitted for Delivery in Ucth, Calabar, Nigeria
Background: Vertical transmission of hepatitis B virus infection during pregnancy and delivery remains the major route of transmission in low resource areas. The objectives of this study were to determine the sero-preval...
Role of Hippocampal Neurogenesis in Regulation of Feeding Behavior during Withdrawal Period in Socialized and Isolated Rats
Introduction: Hippocampal neurogenesis is essential for cognitive functions like memory and learning. However, other functions of hippocampus are not well understood. We aimed to study the role of hippocampus in regulati...
Evaluation of a Chromogenic Medium for the Detection of ESBL with Comparison to Double Disk Synergy Test
Background: Extended Spectrum Beta Lactamase (ESBL) producing bacterial strains are the major causes of nosocomial and community-acquired infections worldwide. The aim of the study was to evaluate the effectiveness of Br...