Diffusion magnetic resonance in cervical carcinoma: the role of apparent diffusion coefficient in the evaluation of treatment response
Journal Title: European Journal of Gynaecological Oncology - Year 2019, Vol 40, Issue 1
Abstract
Purpose: The aim of the study was to determinate the role of apparent diffusion coefficient (ADC) in order to find cut-off values in the evaluation of treatment response. Materials and Methods: A retrospective study was undertaken on MRIs of three groups of patients: 17 with histologically proven cervical carcinoma (group 1), 16 with complete regression after chemo-radiotherapy (group 2), and 46 without pathology (group 3). Three non-overlapping ROIs were manually drawn through neoplastic tissue and normal cervical areas,. regions of interest (ROIs) median values were calculated. Student t-test, ANOVA test, receiver operating characteristic (ROC) curves, and Youden Index were performed. Results: The most important data was obtained by ROC curve and Youden index calculated between free from disease merged group (groups 2+3) and ill patients (group 1): 1.18 x10 -3 mm 2 /s (94% sensibility ,100% specificity), was the cut-off ADC value. Values below this cut-off could be considered as recurrent pathology with high accuracy. Conclusions: ADC represents a fundamental quantitative tool in follow-up of chemo-radiant treatment response in advanced cervical carcinoma.
Authors and Affiliations
G. M. Barelli, F. Carbonetti, V. De Sanctis, I. Martini, P. Bonome, C. Briani, E. Iannicelli
Keywords
Related Articles
- EP ID EP663039
- DOI 10.12892/ejgo4588.2019
- Views 73
- Downloads 0
Resource utilisation and cost of cervical cancer and dysplasia in Croatia
Purpose of investigation: To analyse resource utilisation and costs due to cervical cancer and dysplasia in Croatia. Materials and Methods: Patients diagnosed with cervical cancer were identified from the Croatian Nation...
Immunohistochemical analysis of IQGAP2 in ovarian cancer
IQ motif-containing GTPase-activating protein 2 (IQGAP2) was regarded as a tumor suppressor in some cancers, but its expression pattern in various histological subtypes of ovarian cancer has not been investigated. Immuno...
Taraxacum officinale extract induces antitumorigenic effects in ovarian carcinoma cell lines
Purpose of Investigation: Patients suffering from ovarian cancer often use mistletoe preparations in combination with Taraxacum officinale (dandelion) extracts as supplementary therapy to conventional medicine. However,...
The pleiotropic factor Y-box binding protein-1 enhances the anti-proliferative efficacy of 4-hydroxytamoxifen and fulvestrant on breast cancer cells in vitro
Purpose of investigation: The pleiotropic factor Y-box binding protein-1 (YB-1) is clinically correlated with breast cancer patients’ poor outcome. Due to the intereference of YB-1 with the estrogen receptor, the authors...
Cytoreductive surgery combined with HIPEC in newly diagnosed and recurrent ovarian cancer
Objective: Perioperative intraperitoneal chemotherapy after cytoreductive surgery is used in ovarian cancer treatment. The purpose of the study is the evaluation of the effect of hyperthermic intraoperative intraperitone...