Diminazene aceturate-concentrations in tissues of dogs co-treated with oxtetracycline long acting
Journal Title: Journal of Sustainable Veterinary & Allied Sciences - Year 2021, Vol 1, Issue 1
Abstract
Diminizene aceturate (DA) is the drug of choice for treating Canine Trypanosomosis and Canine Babesiosis in many countries of the world. However, co-administration of the drug with long acting Oxytetracycline (OXY-LA) has been associated with nervous signs suggestive of its toxicity, in treated dogs, even at the normal dose. To investigate what causes this toxicity, fourteen Nigerian indigenous dogs were randomly selected into two groups that comprised six dogs each and the remaining untreated two dogs were used for preparation of tissue standards. One group was treated with DA (3.5mg/kg) alone while the other was, additionally, treated with OXY-LA, 10 minutes post treatment (PT) with DA. Two dogs from each group were sacrificed at 240, 360 and 480 hours, PT and their livers, brains, kidneys, hearts and skeletal muscles were harvested and assayed for DA. Mean DA-concentrations in brains of the DA-OXY-LA group (19.71± 1.31a; 15.86± 2.96a; 9.11± 3.31a) were higher (P≤ 0.05) than 1.39 ± 0.45b; 1.05± 0.29b; 0.71 ± 0.30b of the DA-alone group at 240, 360 and 480 hours, PT, respectively. Also, mean-DA concentration in kidneys (8.00 ±0.46a) of the DA-OXY-LA group was significantly (P≤ 0.05) higher than 3.76±0.32b of the DA-alone group at 360 hours PT. These results suggest that OXY-LA enhances DA-accumulation in the brain and reduces its kidney-elimination, thus making the normal dose to act as overdose, which causes the nervous signs often manifested by treated dogs.
Authors and Affiliations
Onyeachonam, F. O. , Onyeyili, P. A. , Saganuwan, A. S. & Agbo, O. J.
Keywords
Related Articles
- EP ID EP702928
- DOI 10.54328/covm/josvas.2021.010a
- Views 100
- Downloads 0
Heavy metal residues in the offals, flesh and eggs of intensively reared poultry birds in Umuahia, Abia State
Poultry meat and poultry products have gradually become delicacy in Nigeria and are used in most celebrations for entertainment. Therefore there is the need for constant monitoring to ensure they are wholesome and suita...
Evaluation of Aflatoxin B1 in poultry feeds marketed in Nsukka agricultural zone, Enugu State, South Eastern Nigeria
Aflatoxin contamination of poultry feeds is a major challenge to profitable poultry productivity and trade. This study was carried out to evaluate the levels of aflatoxin B1 (AFB1) contamination of poultry feeds commonly...
Effect of season, age, and sex on haematology and serum biochemistry of sport horses
Blood is an important medium for assessing the health status of individual animals: variations in blood parameters of animals are due to several factors such as altitude, feeding level, age, sex, breed, disease, seasonal...
Prevalence of trypanosomes in large and small ruminants in Abia and Rivers State Nigeria
This study investigated the prevalence of trypanosomes in ruminants in Abia and Rivers states, Nigeria by evaluating the trypanosomes parasitaemic profiles of the cattle, sheep and goats studied. Fifty adult cattle (N’da...
Cardiac size appraisals in thoracic radiographs of Nigerian Indigenous dogs: reference guides in clinical practice
The application of radiologic measurement methods has provided very sensitive and more accurate evaluation, compared with subjective assessment, especially in subtle cases of thoracic organ size anomaly. The objective of...