Does Artesunate Treatment normalize Depressed Immunological Parameters Following Plasmodium falciparum Infection?
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 17, Issue 2
Abstract
Plasmodium falciparum is the predominant cause of malaria infection and death in Nigeria and Africa. It perturbs the normal process of immune cells, of which CD 4+ T cells have a crucial relevance for antimalarial immunity. The study aims at determining the effect of artesunate treatment on immunological parameters following Plasmodium falciparum malaria. A randomized non-block experimental design was conducted for the study at Bayelsa State College of Health Technology, Otuogidi-Ogbia, Bayelsa State, Nigeria, between February 2015 and April 2017. Out of 90 subjects enrolled into the study, data collected from 80 subjects (38 males, 42 females, and age range 18-59 years) were analyzed. 40 of the subjects had P. falciparum malaria and the other 40 were negative and were used as controls. 3 ml of blood was collected from the antecubital vein of each enrollee without stasis using a disposable plastic syringe and dispensed into K-EDTA bottles. Immuno-phenotyping was done using the AuRICA system. 20 of the malaria subjects had lymphopenia at presentation. The white cell count was also reduced (P = .05) among the malaria subjects compared with the controls. There was a significant increase in WBC count on completion of the 5-day treatment with the drug (P = .05). Although an increase in the CD4 count after treatment was observed, the mean CD4 count of 1008.1/µl for normal subjects was significantly higher (P = .05) than 889.76/µl for the malaria patients. We conclude that Plasmodium falciparum infection is associated with strong decrease in CD4+ cell activation and depletion of WBC counts. Artesunate in addition to other effects possess immune reconstituting properties.
Authors and Affiliations
Teddy Charles Adias1, Diweni Pere Dick, Vera Achuonye, Joseph Ogwo2
Keywords
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- EP ID EP362400
- DOI 10.9790/0853-1702066972
- Views 86
- Downloads 0
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