Does Rottlerin or its congeners have a potential as adjuvant to antidote therapy of spider/snake venom intoxication?
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2016, Vol 5, Issue 5
Abstract
Rottlerin is a polyphenol natural product isolated from the tree Mallotus philippensis. Rottlerin displays a complex spectrum of pharmacology. Rottlerin has been shown to be an uncoupler of mitochondrial oxidative phosphorylation. It is also known to inhibit the NFAT-5/TonEBP expression. Apart from this it also inhibits the phospholipas A2( PLA2) and phospholipase D enzyme (PLD). Both these enzymes are found in several venoms of the snakes and spider like the brown spider. Rottlerin has also neuroprotective and cardioprotective properties and thus is an ideal candidate for trial in the anti-dote therapy against the deleterious toxic effects of these venoms in humans. This article discusses the hypothetical possibility of its usage in toxic envenomation. Keywords: Rottlerin, Phospholipase A2, Phospholipase D, TonEBP, Venom, toxic
Authors and Affiliations
Manoj G Tyagi
Keywords
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