Does Thyroid Stimulating Hormone (TSH) Levels Affect Anti-Thyroid Peroxidase Antibody (Anti TPO) Titres ? A Hospital Based Study in a Random Population
Journal Title: Journal of Medical Science And clinical Research - Year 2015, Vol 3, Issue 5
Abstract
Autoimmune thyroiditis is a progressive disease of the thyroid gland characterized by the presence of antibodies directed against the thyroid, and by infiltration of the thyroid gland by lymphocytes. Thyroid autoantibodies appear mostly with the presence of lymphocytes in the targeted organ. Anti-thyroid antibodies are auto antibodies targeted against one or more components of the thyroid. The objective of the present study is to evaluate the relationship between TSH and Anti TPO in a random population attending to a tertiary care hospital and also to evaluate the effect of TSH levels on Anti TPO titres in females and males seperately. The present study was a retrospective cross-sectional study carried out on 150 patients attending to Out Patient Department of Krishna Institute Of Medical Sciences a tertiary care hospital. The population included both male and female patients between the age group 3 – 80 yrs. The blood samples were randomly collected from patients with either fasting or non-fasting conditions using BD Gel vacutainers, sample measurements of TSH and Anti TPO were done. In our study, A significant positive correlation was observed in population comprising of normal TSH and elevated Anti TPO (r = 0.334) when We also found a significant (p< 0.03) increase in Anti TPO titres with an increase in TSH levels in females when compared to males (p> 0.06). A raised anti-TPO titer with normal TSH can indicate subclinical Hypothyroidism. We conclude that serum TSH levels correlate with Anti TPO titres. Both Serum TSH along with anti-TPO analyses are essential in determining thyroid status
Authors and Affiliations
N. Rohini MSc Med
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