Drug-Related Problems in Hypertensive Patients with Multiple Comorbidities
Journal Title: Open Access Journal of Pharmaceutical Research - Year 2017, Vol 1, Issue 3
Abstract
Hypertensive patients with multiple comorbidities often received multiple medications to achieve target blood pressure and to treat other comorbidities which can lead to the occurrence of drug-related problems (DRP). The objectives of this study were to identify the DRPs and the most common drugs associated with DRPs in this population. The study was conducted prospectively involving hypertensive patients with multiple comorbidities at a tertiary care centre. Data were obtained from bed head tickets and from the interview with eligible patients. The assessment of DRPs was based on Pharmaceutical Care Network Europe Foundation (PCNE) Classification of DRP tools version 5.01. From the total of 80 patients, 88.8% of the patients had at least one DRP. A total number of 172 DRPs were identified with an average of 2.15 ± 1.5 DRPs per patient. The most frequent category of DRP was interactions (33.7%), followed by adverse reactions (23.9%), drug choice problems (14.5%), dosing problems (13.4%), others (8.1%) and drug use problems (6.4%). Antihypertensive agents were the most common drugs associated with DRPs in this population. Significant associations were found between elderly and the occurrence of adverse reactions, and between renal impairment with the occurrence of drug choice problems and over dosage problems. This study demonstrates that DRPs were frequently observed in hypertensive patients with multiple comorbidities. Thus interventions to resolve these problems are important to ensure the effectiveness and safety of the prescribed medications.
Authors and Affiliations
Redzuan AM*, Ramli AR and Pheng MTH
Keywords
Related Articles
- EP ID EP745761
- DOI 10.23880/oajpr-16000113
- Views 53
- Downloads 0
Perspectives for Treating Alzheimer’s Disease: A Review on Indigeous Plants for Alzheimer Disease
Alzheimer’s disease (AD) is one of the most common forms of dementia. The salient pathological hallmarks of AD are extracellular accumulation of amyloid β peptide (Aβ) forming senile plaques (SP), the aggregates of intr...
Consumption of Wild Tulsi Leaves May Protect Against Methicillin-Resistant Staphylococcus Aurous (MRSA) Infection!
Nosocomial infections are caused by the evolution of methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin resistant Staphylococcus aureus (VRSA). It is concerning because the prevalence of fluoroquinolone an...
The Influence of Cholinergic System on Rheumatoid Arthritis
Rheumatoid arthritis is one of the most prevalent immune-mediated arthritis and is categorized as a chronic, inflammatory and autoimmune disease, which mainly affects the cartilage, synovial joint, and bone, the causes o...
Angiotensin II Contributes to the Pathophysiology of Heart Failure
Angiotensin is a protein hormone; it is a part of the renin-angiotensin system (RAS), that causes blood vessels to become narrower, helps to maintain blood pressure and fluid balance in the body. It is the primary effect...
Effects of Consciousness Energy Healing Treatment on the Improvement of Relative Oral Bioavailability of Low Bioavailable Resveratrol in Male Sprague Dawley Rats
Resveratrol is a natural polyphenol compound found in some plants and fruits that believed to be effective in improving overall health. The biological activity of resveratrol is limited by its poor absorption and first-...