Dynamic bubble tensiometry as a useful tool for assessment of physicochemical interactions of liposomal drug carriers with respiratory tract
Journal Title: Challenges of Modern Technology - Year 2015, Vol 6, Issue 4
Abstract
This article presents an experimental investigation of physicochemical interactions of novel liposomal drug carriers intended for inhalation with model lung surfactant system. The research was done with the use of maximum bubble pressure (MBP) method to measure changes of dynamic surface tension of pulmonary surfactant system after contact with liposomal colloids made of lecithin and lecithin/cholesterol (3:1 w/w) before and after 5 and 10 minutes of nebulisation by pneumatic nebulizer. What is important to point, MBP method allows the discussion of measured phenomena with reference to the time scales characteristic for the changes of alveolar surface area during the breathing cycle. Obtained results may have a potential application during design and development of new therapeutic liposomal formulations for treatment of respiratory as well as systemic diseases.
Authors and Affiliations
Katarzyna Kramek-Romanowska, Tomasz Sosnowski
Keywords
Related Articles
- EP ID EP201060
- DOI -
- Views 79
- Downloads 0
Technological Interface of the City – The Promise of a Real Bottom-Up Urban Planning?
The paper shows how developing social networking services, geo-media applications, e-management tools, and even some particular types of web ‘games’ may contribute to the creation of technological interfaces of our citie...
What is at risk? – an environmental health risk assessment related with pharmaceutical substances in drinking water
Constantly increasing rate of drugs’ consumption can be related with environmental abundance of drug substances and their degradation products. Unused and used drugs are often discharged into municipal wastewaters or lan...
Procedural Generation of Underground Systems with Terrain Features using Schematic Maps and L-systems
This article describes an algorithm for procedural generation of underground systems with terrain features, by processing set of schematic maps. L-system and cellular automata are used to generate final system shapes. Mo...
Effect of the strong magnetic field on copper adsorption processes on activated carbon
In the presented studies an influence of the strong static magnetic field on the process of copper adsorption on activated carbon was analysed. The magnetic field was generated by the annular neodymium magnets, placed at...
Application of the three dimensional models for the public participation in urban design and spatial planning
This paper describes an application of three-dimensional (also “3D”) models respectively to selected types of citizen participation. Detailed descriptions of those types are in the beginning of paper, because they are a...