Dynamics of the vascular wall state in the treatment of patients with hypertension combined with obesity and diabetes mellitus
Journal Title: Міжнародний ендокринологічний журнал - Year 2018, Vol 14, Issue 6
Abstract
Background. Obesity and diabetes mellitus (DM) are considered to be the most important risk factors for arterial hypertension. Endothelial dysfunction is one of the principal causes of hypertension progression. Different schemes of combined drug therapy lead to an improvement in the state of the endothelium. The purpose of the work was to study the dynamics of endothelial function parameters in hypertensive patients with obesity and DM when using combined therapy. Materials and methods. Fifty four patients were enrolled in the study. Anthropometric data, carotid endothelial and aortic function, endothelin, total nitrate-nitrite content were evaluated in all subjects. Results. There was a decrease in both systolic (by 7.36 and 6.36 %, p < 0.05, respectively) and diastolic blood pressure (by 9.2 and 8.29 %, p < 0.05, respectively, in groups 1 and 2). In case of non-fixed drug therapy, the index of aortic stiffness (IAS) decreased by 7.05 % (p > 0.1), the intima-media thickness (IMT) — by 5.48 % (p > 0.1), the level of endothelin-1 — by 31.27 % (p > 0.1), whereas total nitric oxide (NO) content increased by 8.35 % (p > 0.1), endothelium-dependent vasodilation (EDVD) — by 10.5 % (p > 0.1). With a fixed combination of antihypertensive drugs, more pronounced changes occurred: IAS decreased by 10.96 % (p < 0.05), IMT — by 8 %, endothelin-1 — by 31.52 % (p < 0.05), while total NO increased by 8.7 % (p < 0.05), and EDVD — by 11.8 % (p < 0.05). Conclusions. In hypertensive patients with obesity and DM, there is an increase in the arterial stiffness, intima-media thickness, an increase in the level of endothelin, and a decrease in EDVD and the level of total nitrates. Fixed combination stimulates EDVD, improves the mechanisms of autoregulation and elastic properties of muscular vessels, and is more significant in controlling blood pressure.
Authors and Affiliations
B. A. Shelest
Keywords
Related Articles
- EP ID EP412503
- DOI 10.22141/2224-0721.14.6.2018.146066
- Views 64
- Downloads 0
Iodine Deficiency: Where Are We Now? (Efficiency of Belarusian Strategy in Elimination of Iodine Deficiency: 15-year Experience)
Between the former Soviet republics, which became independent states, there are big differences in the state of iodine provision and in technology to eliminate iodine deficiency in the diet of the population. The publica...
Diabetes Mellitus and Some Microelements
This literature review describes the role of the different trace elements in the development, progression and prevention of diabetes mellitus and its complications. The results of the studies of microelements in blood, u...
Clinical efficiency of aerobic exercises in the young patients with type 1 diabetes mellitus
Background. The purpose of the study is to investigate the effect of regular aerobic physical exercises with 6-point intensity by Borg scale on glycemic profile, insulin sensitivity, and quality of life of patients with...
Thyroid Disease in Women of Reproductive Age: Preconception Preparation and Management during Pregnancy
During pregnancy, the metabolism of iodine and thyroid hormone changes that is an important factor in the diagnosis and treatment of thyroid diseases in pregnant women and women who are planning to become pregnant. It is...
The effectiveness of methylcobalamin in the complex treatment of diabetic peripheral neuropathy
Background. Diabetic neuropathy is the most common complication of diabetes mellitus (DM), found in 30–90 % of patients. The relevance of the study is due to the prevalence of diabetic neuropathy, as well as assessing th...