Echocardiographic Evidence of Early Diastolic Dysfunction in Asymptomatic Children with Osteogenesis Imperfecta
Journal Title: Sultan Qaboos University Medical Journal - Year 2015, Vol 15, Issue 4
Abstract
Objectives: Structural and functional cardiovascular abnormalities have been reported in adults with osteogenesis imperfecta (OI); however, there is a lack of paediatric literature on this topic. Tis study aimed to investigate cardiovascular abnormalities in children with OI in comparison to a control group. Methods: Tis case-control study was conducted at the Sultan Qaboos University Hospital in Muscat, Oman, between May 2013 and August 2014. Data from eight patients with OI and 24 healthy controls were compared using conventional and tissue Doppler echocardiography (TDE). Results: Te OI group had signifcantly lower peak early mitral valve flow velocity (P = 0.027), peak a-wave reversal in the pulmonary vein (P = 0.030) and peak early diastolic velocity of the mitral valve and upper septum (P = 0.001 each). Te peak late diastolic velocities of the mitral valve (P = 0.002) and the upper septum (P = 0.037) were signifcantly higher in the OI group; however, the peak early/late diastolic velocity ratios of the mitral valve (P = 0.002) and upper septum (P = 0.001) were signifcantly lower. Left ventricular dimensions and aortic and pulmonary artery diameters were larger in the OI group when indexed for body surface area. Both groups had normal systolic cardiac function. Conclusion: Children with OI had normal systolic cardiac function. However, changes in myocardial tissue Doppler velocities were suggestive of early diastolic cardiac dysfunction. Tey also had increased left ventricular dimensions and greater vessel diameters. Tese fndings indicate the need for early and detailed structural and functional echocardiographic assessment and follow-up of young patients with OI.
Authors and Affiliations
Khalfan S. Al-Senaidi| Departments of Child Health, Sultan Qaboos University Hospital, Muscat, Oman, Irfan Ullah| Departments of Child Health, Sultan Qaboos University Hospital, Muscat, Oman, Hashim Javad| Departments of Child Health, Sultan Qaboos University Hospital, Muscat, Oman, Murtadha Al-Khabori| Departments of Haematology, Sultan Qaboos University Hospital, Muscat, Oman, Saif Al-Yaarubi| Departments of Child Health, Sultan Qaboos University Hospital, Muscat, Oman
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