Ectopic Cushing’s syndrome: ACTH-producing pulmonary carcinoid. A case report
Journal Title: Міжнародний ендокринологічний журнал - Year 2018, Vol 14, Issue 4
Abstract
The article describes a clinical case of ectopic Cushing’s syndrome in a man aged 39 years. Characteristic signs of hypercorticism (obesity, arterial hypertension, striae, thinning of the extremities, myasthenia, diabetes mellitus, hypokalemia) developed over a period of 1.5 years. However, the diagnosis of Cushing’s syndrome was established after hospitalization for arterial hypertension. Hormones: adrenocorticotropic hormone (ACTH) — 110 pg/ml (7–69), daily urinary cortisol excretion — 3,400 μg/24 h (28.5–213.7). Magnetic resonance imaging of the pituitary gland, multislice helical computed tomography (MHCT) of the abdominal cavity organs and [111In-DTPA-D-Phe1]-octreotide scintigraphy have not revealed a tumor. Only after the MHCT of the thoracic organs, carcinoid of the left lung was found. The patient was operated, and then during 2 months he almost recovered. Pathohistological conclusion: well-differentiated neuroendocrine tumor. Level of cell expression of cytoplasmic markers of neuroendocrine differentiation: synaptophysin (+), chromogranin A (+), CD56 (–), CD68 (–). The proliferation index Ki 67 was 1 %. Hormones: ACTH — 34 pg/ml, serum cortisol — 13.69 μg/dl (6.2–19).
Authors and Affiliations
M. L. Kyryliuk, M. K. Tedeieiva
Modern Views on the Algorithm of Management of Pregnant Women and Women in Labor with Diffuse Toxic Goiter
The article presents the modern views and data on the risk factors, mechanisms of development, clinical features and complications of diffuse toxic goiter during the pregnancy, labor, in the postpartum period and in newb...
The Influence of Metabolic Disorders on Clinical Manifestations of Osteoarthritis and the Method for Predicting Its Course
The objective of the research: to study the impact of metabolic syndrome parameters on the clinical signs of osteoarthritis and to develop the method for predicting osteoarthritis severity based on components of the meta...
Results of Epidemiological Surveys of Iodine Deficiency Disorders Prevalence in Fergana Region of Republic of Uzbekistan
In spite of extant programs aimed to liquidation of iodine deficiency, Republic of Uzbekistan still remains the zone of high prevalence of iodine deficiency disorders (IDD). Due to epidemiological surveys it has been def...
Primary hyperaldosteronism. Mechanisms and consequences of pathological influence on an organism (review of literature)
The work is based on the analysis of world literature data on primary hyperaldosteronism. The data on mechanisms of pathological influences of excessive autonomous aldosterone secretion on the body systems are given. The...
Polycystic Ovary Syndrome: Laboratory Diagnosis of Hyperandrogenic Status of a Woman (A Review of the Article «The Polycystic Ovary Syndrome: a Position Statement from the European Society of Endocrinology», October 2014)
The article presents the modern laboratory aspects for evaluation of hyperandrogenism according to published in October 2014 document of the European Society of Endocrinology in the diagnosis and treatment of polycystic...