Effect of alternate-day-fasting combined with Lingguizhugan Decoction on blood lipid profiles of hyperlipidemic rats
Journal Title: Traditional Medicine Research - Year 2018, Vol 3, Issue 3
Abstract
Objective: To explore the effects of alternate-day-fasting (ADF) therapy combined with Lingguizhugan Decoction (LD) on blood lipid profiles of hyperlipidemic rats. Methods: Rats were randomly assigned into high-fat-diet (HF) group and normal-diet (ND) group. Hyperlipidemic rats fed with high-fat-diet for 5 weeks were randomly divided into ADF group, alternate-day-fasting with LD (ALG) group and model control (MC) group. The rats in ALG and ADF group were deprived of food for 24 h every other day for 4 weeks. Rats in ALG group were administrated with LD at fasting day. After 4 weeks of ADF therapy, plasma TC, TG, LDL-c and HDL-c were measured in each group. Expression of miR-143 and PPAR-γ protein from adipose was also analyzed. Results: When compared with MC group, after 4 weeks of ADF or combined ADF and LD therapy, the body weight was evidently reduced in ADF and ALG groups (P = 0.028, P = 0.036 by wk 8). The levels of plasma TC and TG decreased in ADF group and ALG group, which were significantly lower than those in MC group (P < 0.001, P = 0.045; P < 0.001, P = 0.005). However, the body weight and level of TC and TG in ALG group showed non-statistical difference in comparison with ADF group (ALG vs. ADF, P > 0.05). Expression of miR-143 and PPAR-γ were higher in MC group than that in NC group (P < 0.001). Compared with MC group, expression of miR-143 and PPAR-γ were significantly decreased in ADF (P = 0.038, P = 0.015) and ALG (P = 0.007, P < 0.001) groups. When compared with ADF group, expression of miR-143 and PPAR-γ were significantly decreased in ALG (P = 0.041, P = 0.046) group. Conclusion: ADF therapy alone not only reduced blood lipids, but also inhibited miR-143 and PPAR-γ protein expression in visceral adipose tissue. However, LD couldn’t reduce the levels of blood lipid profiles more effectively than using ADF alone. Perhaps the effects of LD combined with ADF in the prevention of hyperlipidemia need further exploration.
Authors and Affiliations
Jun-Jie Zhang, Xian-Zhi He, Guo-Shun Peng, Zhen-Kun Wang, Bin Ke, Jian Qin
Keywords
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- EP ID EP45234
- DOI 10.12032/TMR201811074
- Views 288
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