Effect of apigenin, kaempferol and resveratrol on the expression of interleukin-1betaand tumor necrosis factor-alpha genes in J774.2 macrophages.
Journal Title: Pharmacological Reports - Year 2005, Vol 57, Issue 3
Abstract
Flavonoids have been reported to bring benefits in lowering inflammation,oxidative stress and exert positive effects in cancer and cardiovascular and chronic inflammatory diseases.Apigenin, kaempferol and resveratrol present in fruits, vegetables and grain were investigated for theireffect on the synthesis of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) attranscriptional level in lipopolysaccharide (LPS)-stimulated J774.2 macrophages. Apigenin (30 muM), kaempferol(30 muM) and resveratrol (50 muM) significantly decreased the number of TNF-alpha mRNA copies in LPS-activatedJ774.2 macrophages. Apigenin and kaempferol caused inhibition of IL-1beta gene expression in J774.2 macrophages,but resveratrol was ineffective. These results indicate that apigenin, kaempferol and resveratrol exertinhibitory effects on the TNF-alpha and except for of resveratrol on IL-1beta gene expression in J774.2macrophages at the transcriptional level. In addition, the studied compounds may be the mediators responsiblefor protective role of a diet high in fruits and vegetables in the cardiovascular and inflammatory diseases.
Authors and Affiliations
Jan Kowalski, Arkadiusz Samojedny, Monika Paul, Grażyna Pietsz, Tadeusz Wilczok
Keywords
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