Effect Of Aqueous and Ethanol Leaf Extracts Of Musa Paradisiaca on Serum Protein, Liver And Kidney Function In Albino Wistar Rats
Journal Title: IOSR Journal of Biotechnology and Biochemistry (IOSR-JBB - Year 2018, Vol 4, Issue 6
Abstract
The effect of aqueous and ethanol leaf extracts of Musa paradisiaca on serum proteins, liver and kidney function in albino rats was evaluated. Thirty-five (35) albino Wistar rats weighing between 120 -150g were divided into five (5) groups with seven rats in each group. Group A served as control while Groups B and C received 250mg/kg and 1000 mg/kg of the aqueous extract daily for 28 days. Groups D and E received 250 mg/kg and 1000 mg/kg of the ethanol extract daily for 28 days. Blood samples were obtained through cardiac puncture and centrifuged to obtain serum which was used for biochemical assays. Serum liver enzymes (ALT, AST and ALP) activities, protein, bilirubin, urea, creatinine and electrolytes concentration were assayed. The result showed that urea and creatinine levels were significantly (p<0.05) decreased in the test groups except in group B which urea and Cl- were significantly (p<0.05) increased. The electrolytes concentrations were nonsignificantly (p<0.05) decreased except K+ which was non-significantly (p<0.05) increased in group B. ALT and AST activities were decrease in all groups except in group B where significant (p<0.05) increase was observed. The low dose of aqueous extract of Musa paradisiaca leaf had toxic effect on serum proteins, liver and kidney, while the high dose of aqueous, low and high doses of ethanol leaf extract showed positive effect on the serum proteins and indices of liver and kidney function.
Authors and Affiliations
Oboso E. Etim, Arit J. Ekpo, Utibe E. Bassey
Keywords
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- EP ID EP415193
- DOI 10.9790/264X-0406011619.
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