Effect of aqueous extract of Tribulus terrestris on the activity of major platelets factors and the treatment of immune thrombocytopenic purpura
Journal Title: Health and Medical Research Journal - Year 2021, Vol 1, Issue 1
Abstract
Introduction: Idiopathic thrombocytopenic purpura (ITP), an autoimmune disease with decreased platelet counts needs corticosteroids, intravenous immunoglobulin (IVIg), and anti-Rho in the first line and splenectomy, rituximab, and thrombopoietin in the second line of therapy. The present study reveals the application of the aqueous extract Tribulus terrestris (T. terrestris) plant in ITP treatment. Methods: A standard aqueous extract of T. terrestris was given orally to twenty patients who were newly diagnosed with ITP in the form of 500 mg capsules (three times per day for14 days). Blood samples were taken from patients before, during, and after two weeks of treatment to count plasma Platelet Factor 4 (PF4), serotonin factor, and Von Willebrand Factor (VWF). Results: We observed a significant increase in the platelet count among all patients, while plasma platelets and assay factor 4 decreased and VWF increased during and after treatment. Serotonin was increased on days 1 and 14 and slightly decreased once the treatment was completed. Conclusion: Our findings suggest that T. terrestris extract can be considered an efficient alternative medicine for the treatment of ITP.
Authors and Affiliations
Soodabeh Aghapour; Ali Mostafaie; Mehrdad Payandeh; Kamran Mansouri; Fariba Sohrabi; Zahra Koolivand
Keywords
Related Articles
- EP ID EP709345
- DOI 10.22034/HMRJ.2021.139993
- Views 106
- Downloads 0
Examination of the oral health-related quality of life in rural pregnant women after receiving the Health Evolution Plan services
Introduction: The aim of this study was to examine the quality of life regarding the oral health in pregnant women in the village of Robat Karim after receiving the Health Evolution Plan services. Methods: The research...
Pre-operation and post-operation anxiety in cesarean candidates
Introduction: Women undergoing cesarean section may have some difficulties in self-care and the care of their baby due to post-operative pain as well. If anxiety-inducing factors in the mother are not controlled or treat...
Comparison of awareness of radiation protection, dose levels, and complications of radiation exposure in imaging procedures between radiology residents/undergraduate students and radiology staff: A cross-sectional study
introduction: Radiographic tools are one of the most instruments in hospitals. The ionizing radiation process occurs in radiographic instruments. The ionizing radiation causes side effects in the users. Lack of knowledge...
The association between health-promoting lifestyle profile and chronic diseases with self-efficacy in performing health behaviors among Iranian elderly: A cross-sectional study
Introduction: Health-promoting lifestyle profile (HPLP) includes behaviors that prevent diseases and promote health. Self-efficacy is one of the most important factors that affect adopting a healthy lifestyle. This study...
Effect of aqueous extract of Tribulus terrestris on the activity of major platelets factors and the treatment of immune thrombocytopenic purpura
Introduction: Idiopathic thrombocytopenic purpura (ITP), an autoimmune disease with decreased platelet counts needs corticosteroids, intravenous immunoglobulin (IVIg), and anti-Rho in the first line and splenectomy, ritu...