Effect of atorvastatin on hard exudates in type 2 diabetic patients with normal lipid profile
Journal Title: Indian Journal of Clinical and Experimental Ophthalmology - Year 2018, Vol 4, Issue 2
Abstract
Purpose To evaluate the effect of Atorvastatin on hard exudates in diabetic retinopathy in type 2 diabetic patients with normal lipid profileMaterials and Methods Prospective study of 50 patients with clinically significant macular edema involving centre was done over 2 years 201516 We excluded patients with type 1 diabetes mellitus patients with nephropathy heart disease dyslipidemic patients patients with laser treatment within 3 months of enrollment patients with proliferative diabetic retinopathy requiring laser treatment Detailed history was taken and thorough examination was done with 90 D lens for size and extent of clinically significant macular edema and grading of hard exudates OCT was done for maximum retinal thickness The outcome measures were visual acuity change in grade of hard exudates and maximum retinal thickness Change in maximum retinal thickness by 30 was considered as significant reduction of macular edema Patient had minimum follow up of 6 monthsResults Of 50 patients 34 were male and 16 female Mean follow up period was 10540 months Baseline mean visual acuity was 07304 log MAR and baseline mean MRT was 36003 3094 Patients with grade 3 hard exudates were 6 with grade 4 hard exudates were 28 and with grade 5 hard exudates were 16 at baseline Final mean visual acuity was 07604 log MAR Mean MRT at final visit was 2846 483 34 patients 68 showed improvement by one grade and 2 patients showed improvement by two grade The grade of hard exudates remained unchanged in 12 patients 24 and deteriorated in 2 patientsConclusion Atorvastatin leads to significant improvement in grade of hard exudates in clinically significant macular edema and decrease in maximum retinal thickness on OCT However visual acuity status was not significant over short term follow upKeywords Atorvastatin Clinically significant macular edema Hard exudates
Authors and Affiliations
Anubha Bhatti, Subina Narang
Keywords
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- EP ID EP474195
- DOI 10.18231/2395-1451.2018.0039
- Views 93
- Downloads 0
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