Effect of Centella asiatica against anti-tuberculosis drugs-induced hepatotoxicity: Involvement of mitochondria and oxidative stress
Journal Title: The Journal of Phytopharmacology - Year 2014, Vol 3, Issue 4
Abstract
The liver is an integral organ in the body and plays a vital role for the metabolism of endogenous and exogenous agents. Drug-induced liver toxicity is one of most common cause of liver injury. It accounts for approximately one-half of the cases of acute liver failure and mimics all forms of acute and chronic liver disease. Hepatotoxicity is associated with the first line antituberculosis drugs such as isoniazid and rifampicin. Therefore, there is need of pharmacological interventions for the treatment of hepatotoxicity. The present study was designed to evaluate the hepatoprotective effect of the Centella asiatica extract on anti-TB drugs-induced hepatotoxicity. Hepatotoxicity was induced by administration of anti-TB drugs (isoniazid and rifampicin). Hepatotoxicity was assessed by significant elevation in oxidative stress, mitochondrial complex alterations and elevated levels of liver marker enzymes. Treatment with Centella asiatica (20, 40 mg/kg p.o.) attenuated the anti-TB drugs induced oxidative stress, mitochondrial complex alterations and elevated levels of liver marker enzymes (viz. SGOT, SGPT, ALP). Histopathological studies also show the promising effect. Therefore, the present study shows the hepatotoprotective effect of Centella asiatica. Therefore, Centella asiatica could be a new pharmacological intervention in the treatment of hepatotoxicity.
Authors and Affiliations
Vinay Kumar, Ankur Sharma , Lalit Machawal, K. Nagarajan, Shadab A. Siddiqui
Keywords
Related Articles
- EP ID EP49578
- DOI -
- Views 239
- Downloads 0
Antifungal activity of Bacillus species in bio-control of different plant pathogens
Background: Plant diseases are caused mainly by fungi, bacteria, viruses and nematodes. Biocontrol of plant disease involves the use of an organism or organisms to reduce disease which includes management of resident p...
Plants used in Bandjoun village (La'Djo) to cure infectious diseases: An ethnopharmacology survey and in-vitro TimeKill Assessment of some of them against Escherichia coli
An ethnopharmacology survey concerning the medicinal plants used in Bandjoun village (La'Djo) to cure infectious diseases was carried out in three districts of this village. The survey led to the identification of 79 m...
Inhibition of Dehydrogenase Activity in Pathogenic Bacteria Isolates by Aqueous Extract of Curcuma Longa (Turmeric) Rhizome
Inhibition of dehydrogenase activity in pathogenic Gram – positive and Gram – negative microorganism exposed to ethanol extract of curcuma longa was used as an index for assessment of its antibacterial activity. Assay o...
Lipid-lowering effect of Vernonia amygdalina leaf extracts on Triton WR 1339 – induced hyperlipidaemia in the rats
Vernonia amygdalina is a common plant reported to have several health benefits. This study investigated the dose dependent hypolipidemic potentials of the leaf extracts, following Triton WR 1339 induced hyperlipidemia....
Field based efficacy assessment of some ethno-herbal practice as an alternative anthelminthic approach in Black Bengal goat in Tribal area of Bengal
Bengal goats reared in semi-intensive system by marginal tribal farmers of West Bengal, India are naturally infested with endoparasites due to different managemental and climatic factors. Easily available ethnoveterina...