Effect of Combination of Three Herbs (Akaki Extract) on Frontal Lobe of the Albino Wistar Rat
Journal Title: International Journal of Health Sciences and Research - Year 2017, Vol 7, Issue 12
Abstract
The combination of Costus afer, Sarcocephalus latifolius, and Culcasia scandensreferred to Akaki is used in the management of psychiatric disorders. We investigated the effects of Akaki on spatial memory and histology of the frontal lobe. Phytochemical analysis was conducted using standard methods. Twenty rats with average weights of 200g were used and divided into 4 groups of 5 rats each (n=5). The rats in group A served as control received 0.1ml saline while rats in groups B, C & D were treated daily with 3mg/kg, 6mg/kg and 9mg/kg of the extract for seven days. Phytochemical analysis revealed presences saponins, phenol, flavonoids, tannin and glycosides. Behavioural study was performed using the T-maze to assess spatial memory and H&E for histological changes. The extract demonstrated ability to improved spatial memory of the reward arm in the T-maze neurobehavioral test. The mean difference was significant at level (p<0.05). The histological study showed dose dependent increase in neuronal population at low doses. The high dose group which received 9 mg/kg of the akaki extract showed focal and liquefactive necrosis in few areas. Akaki extract contain active agents, improved memory and exhibited biphasic dose dependent.
Authors and Affiliations
Elizabeth Finbarrs-Bello
Keywords
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