EFFECT OF DICLOFENAC ON THE PHARMACOKINETICS OF SULPHADIMIDINE IN WEST AFRICAN DWARF (WAD) GOATS FOLLOWING INTRAMUSCULAR ADMINISTRATION.
Journal Title: European Journal of Biomedical and Pharmaceutical Sciences - Year 2019, Vol 6, Issue 11
Abstract
Sulphadimidine an antimicrobial is widely used in veterinary medicine in the treatment of animal diseases. It can be combined with non-steroidal anti-inflammatory drugs to treat various systemic infections associated with fever, pain and other inflammatory conditions. This study was carried out to determine the effect of diclofenac on the pharmacokinetics of sulphadimidine in West African Dwarf goats. Eight (8) WAD goats of 1-2 years old with a mean weight of 17.73 0.89 kg were separated into two groups of four animals consisting of two males and two female goats each. Sulphadimdine sodium (33.3%) was administered at a dose of 100 mg/kg body weight and diclofenac (2.5%) was administered at a dose of 2.5mg/kg body weight. Sulphadimidine was administered into the right gluteal muscle to goats in group 1. To the goats in group 2, sulphadimidine was administered into the right gluteal muscle and diclofenac into the left gluteal muscle concurrently. There was no significant difference (p>0.05) in pharmacokinetic parameters between the WAD goats treated with sulphadimidine alone and sulphadimidine co-administered with diclofenac. Based on the results obtained, it can be concluded that diclofenac can be safely and effectively combined with sulphadimidine to treat animal diseases associated with fever, pain and other inflammatory conditions.
Authors and Affiliations
Dr. Agbo J. O.
Keywords
Related Articles
- EP ID EP672266
- DOI -
- Views 198
- Downloads 0
SYNERGISTIC EFFECT OF GALANTAMINE CARRIED ON A NOVEL NANO-DRUG DELIVERY SYSTEM ON INDUCED HEART DISORDERS IN ALZHEIMER’S DISEASE
Background: Alzheimer's disease AD, the most common form of dementia, usually presents with cardiac disorders including heart failure. The aim of the present study was to verify that the curative role of Galantamine (the...
SONOGRAPHIC EVALUATION OF SEVERITY OF NATIVE MITRAL VALVULAR REGURGITATION AMONG HEART FAILURE PATIENTS
Mitral regurgitation (MR) may develop in patients with heart failure without organic mitral valve disease and contribute to worsening symptoms and survival. It has long been recognized as an important cause of morbidity...
Evaluating the Effect of Selected Medicinal Plant Extracts and their Synergistic Effect with Metronidazole against Entamoeba histolytica
Introduction: Intestinal infection with Entamoeba histolytica is an important cause of diarrhoea world-wide especially where sanitation conditions are poor. Medicinal plants have played a significant role in various trad...
THE DIFFERENCE OF EFFECTIVENESS OF LOCAL CLEANING AND ANTIFUNGAL APPLICATION IN THE TREATMENT OF OTOMYCOSIS BETWEEN AFRICAN AND NON AFRICAN PATIENTS IN LIBERIA
Objective: To determine the difference of effectiveness of the local toileting and the application of antifungal creams in the management of otomycosis between African and Non African patients in Liberia. Method: Cross –...
SUBMUCOSAL DIATHERMY VERSUS BIPOLAR SURFACE CAUTERY FOR HYPERTROPHIED INFERIOR TURBINATE, COMPARATIVE ANALYSIS
Objective: To evaluate and compare outcome of submucosal diathermy versus bipolar surface cautery for hypertrophy of the inferior turbinate. Methods: Retrospective analysis of 123 patient who underwent turbinate surgery,...