Effect of Different Fractions of Lawsonia inermis Linn on Haematobiochemical Changes, Osmotic Fragility and Lipid Profile in Streptozotocin-induced Diabetic Wistar Rats
Journal Title: Journal of Applied Veterinary Sciences - Year 2024, Vol 9, Issue 3
Abstract
Diabetes mellitus is a major health challenge that has harmful effects on the quality of life globally as a result of its numerous complications. This study aimed to evaluate the positive modulatory effect of Lawsonia inermis (LI) Linn on various haemobiochemical parameters and lipid profiles in streptozotocin-induced diabetic rats. Ten groups of diabetic rats (n = 5) were orally administered 50 and 100 mg/kg of three different fractions of Lawsonia inermis: metformin (500 mg/kg) and glibenclamide (5 mg/kg), whereas untreated hyperglycaemic and normoglycaemic rats received distilled water. The results showed increased red blood cells (RBC) in treated rats compared to untreated diabetic rats. Hb, MCV, MCH, and MCHC decreased nonsignificantly, whereas WBC increased nonsignificantly. Neutrophil increased non-significantly in diabetic, untreated rats, while all the treatment groups decreased non-significantly. Lymphocytes and monocytes increased non-significantly (p > 0.05). Most treatment groups showed a non-significant (p > 0.05) increase in the platelet count. The ALT levels decreased non-significantly (p > 0.05) compared to normoglycemic rats. The AST levels decreased significantly (p < 0.01). ALP decreased non-significantly in both treated and untreated groups, whereas bilirubin did not show any significant changes. Creatinine and urea levels in untreated diabetic rats increased non-significantly, while treatment groups decreased non-significantly. Lawsonia inermis-treated rats showed significant improvement in erythrocytic fragility, while glycated haemoglobin in untreated-diabetic and glibenclamide-treated rats increased significantly (p > 0.001). Triglycerides and high-density lipoprotein decreased non-significantly, while low-density lipoprotein increased non-significantly (p > 0.05) in diabetic untreated rats. All treatment groups showed a non-significant (P > 0.05)Â decrease in low-density lipoprotein. Lawsonia inermis showed a significant positive modulatory effect on the haemobiochemical changes, glycated Hb, osmotic fragility, and lipid profile in streptozotocin-induced diabetic rats.
Authors and Affiliations
Abdulfatai AREMU,Olayinka Oridupa,Norazah Bashar,
Keywords
Related Articles
- EP ID EP739050
- DOI -
- Views 73
- Downloads 0
Detection of Mold and Aflatoxin B1 in Mayonnaise Product from Egyptian Markets by HPLC
Egyptian consumers' demand and preference for sauces like mayonnaise have increased lately. The processing and packaging techniques of such products may safeguard the consumer from bacterial hazards, although mold and/or...
Biochemical and Histopathological Assessment of Zinc Acetate-Induced Nephrotoxicity in Male Albino Rats
Despite the fact that zinc is recognized to be less hazardous than other heavy metals, e.g. cadmium, lead, mercury and arsenic, it may cause acute and chronic toxicities in case of exposure to high doses. Aims of the stu...
Struvıte Bladder Stone in A Cat Wıth Hyperthyroıdısm: Case study
Urinary crystals and uroliths could harm cats by causing local or systemic symptoms that could vary from mild to severe. Regardless of the type of stone, the diagnostic methods are the same. However, in addition to det...
Camel Trypanosomiasis “Dhukaan” in Lower Juba Region of Somalia: Importance and Microscopic Survey
Camel trypanosomiasis is the most significant animal disease in the camel zone of Somalia. The Somali camel is also found in the southern areas of Somalia, which have a high density of vectors, including Glossina. The ec...
Detection of Aflatoxigenic Fungi in Poultry Feed
Mycotoxins are poisonous biomolecules produced as secondary metabolites by some fungal species, as they grow on various substrates under suitable growth conditions. Approximately, 83% of these deaths occur in East Asia a...