Effect of Dimethoate and Chlorpyrifos in Hepatic and Renal Function of People Belonging to Risk Groups in Iraklia Serres (N. Greece)
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2014, Vol 4, Issue 4
Abstract
Aims: There is little evidence concerning the effects of organophosphates in the liver of healthy individuals, and the existing researches come to contradictive results. In this study, we evaluated the influence of organophosphates (Dimethoate, Chlorpyrifos) in liver and renal function of healthy exposed workers, not experiencing symptoms of serious intoxication. Study Design: Measure serum activity of the liver function monitoring enzymes SGPT, SGOT, γ-GT and ALP and serum concentration of the renal function indicative biomarkers urea and creatinine. Place and Duration of Study: Sample were collected in Health Care Greece of Iraklia Serres and analyzed in Department of Medical Laboratory Studies Alexander Technological Educational Institute of Thessaloniki. Methodology: Blood samples were collected from 112 individuals, randomly selected from villagers of N. Greece. 42 of them were organophosphates (OP) applicators aged less than 50 years old (mean age 37 years old) and 42 were OP applicators older than 50 years old (mean age 58 years old); while 28 individuals (13 of them were less than 50 years old and 15 older than 50 years) were not OP applicators and used as control groups. Results: A remarkable and statistically significant increase (P < 0.05) in the main liver-function monitoring enzymes (SGOT, SGPT, γ-GT) was observed in exposed people compared to the control group. Increase in ALP values compared to not exposed individuals was not observed. Concerning the kidneys, data analysis shows that there is not any significant effect on their operation by the use of OP. Conclusion: The age of OP applicators and the time past between the application and the measure of blood serum seems to play an important role in the values of hepatic enzymes. While the renal indicators seemed not so much affected, as organophosphates are rapidly metabolized in human organism.
Authors and Affiliations
George Andreadis, Triantafyllos Albanis, Eleni Andreadou, Styliani Mitka, Faedra Eleftheriou, Dimitra Lampropoulou, Nikolaos Avramidis, Dimitrios Patoucheas
Keywords
Related Articles
- EP ID EP348502
- DOI 10.9734/BJMMR/2014/5828
- Views 74
- Downloads 0
Patient Dignity in Coronary Care: Psychometrics of the Persian Version of the Patient Dignity Inventory
Aim: The Patient Dignity Inventory (PDI) is a valid and reliable questionnaire. This questionnaire was created by Chochinov in 2002 and is used to measure various sources of distress related to the dignity of patients. T...
Gangrenous Purpura Fulminans Associated with Influenza A Infection
Gangrenous Purpura Fulminans Associated with Influenza A Infection Background and Purpose: Purpura fulminans (PF) is a rapidly progressive disease of small-vessel thrombosis and hemorrhagic skin infarctions with high mor...
Brief Useful Comments on Laparoscopic Surgery in Acute Abdomen
The use of laparoscopic surgery tends to become more and more popular, nowadays. It has also been extended in the management of acute abdominal disease as a diagnostic and as a therapeutic tool. However, its therapeutic...
Occupational Risk Factors for Musculoskeletal Disorders among Operation Room Nurses at Cairo University Hospitals
Aims: To assess the occupational risk factors that contribute to the occurrence of work- related musculoskeletal disorders among Operation Room (OR) nurses and MSDs relation to biomarker c-telopeptide of type II collag...
Reproductive Hormonal Profile of Post-menopausal Women in Ebonyi State, Nigeria
Background: Assessment of the concentrations of reproductive hormones during post-menopause has been suggested as a confirmatory test for menopause due to irregularities in rise and fall of sex hormones in menopausal tra...