EFFECT OF ERYTHROMYCINE IN ALTERED GASTRIC MOTILITY AND PH IN WISTAR RATS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 1
Abstract
Drug absorption through the gastrointestinal tract plays a major role in determining the systemic exposure of the drugs when administered by oral route. The physicochemical properties of the drug like particle size, polymorphism, salt forms, lipophilicity and dosage form characteristics like disintegration time, dissolution time, manufacturing variables, pharmaceutical ingredients, nature and type of dosage form are known to impact drug absorption. Apart from physicochemical properties of drug various patient related factors like gastric emptying, gastric pH, intestinal transit, disease state and GI blood flow can affect the drug absorption to a huge extent. The change in the gastric emptying, intestinal transit and gastric pH in this study was accomplished by using Metoclopramide, Atropine, Neostigmine and Omeprazole. Metoclopramide also significantly increases the blood flow by about 67.3 and 29.7% at the duodenum and jejunum. In the present study, Patient related parameters were conducted for erythromycin in presence of metoclopromide, atropine, neostigmine and omeprazole in rats. Charcoal meal test were performed in rats to confirm the effect of above drugs on gastrointestinal motility.
Authors and Affiliations
Abhay Joshi , Prashant Tayade , Shrikant A Jagtap , Anasuya Patel , Yuvraj Girbane
Keywords
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