Effect of Gongronema Latifolium Leaves Ethanolic Extract on Paracetamol-Induced Hepatotoxicity in Rats
Journal Title: Journal of Physiology and Pharmacology Advances - Year 2014, Vol 4, Issue 2
Abstract
Gongronema latifolium is a perennial edible plant used locally, especially in the South-Eastern Nigeria as spice in foods or eaten raw for its medicinal benefit. It has been noted for its anti-diabetic, anti-hypertensive and anti-oxidative properties among others. This study investigates the effect of the Gongronema latifolium leaf ethanolic (GLE) extract on paracetamol-induced hepatotoxicity in rats. Twenty four wister albino rats were randomly placed into six (6) groups of four (4) animals per group. Two groups serve as control and received either olive oil (oral) or paracetamol (200mg/ kg bw, ip) alone. Three experimental groups received paracetamol(200mg/kg bw,ip) before, after or simultaneously with administration of GLE (1g/kg bw, oral). The remaining group received extract (1g/kg bw, oral) alone. Animals were sacrificed after 6 days of treatment and serum observed for liver function parameters. The results show significant (P<0.05) increases in activities of ALT and ALP, and total bilirubin levels for animal group treated paracetamol alone. The group treated paracetamol and GLE simultaneously showed significant reduction in activities and level of the above parameters. Also pre- and post-hepatotoxic administration of GLE show normalization of parameters, except for ALP activity which remained high. Thus Gongronema latifolium ethanolic extract (GLE) may have both hepatoprotective and antihepatotoxic effects on paracetamol-induced toxicity in rats.
Authors and Affiliations
E. A. Ogbonnaya , S. O. Uanseoje , S. I. Ojeaburu
Keywords
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