Effect of injection volume on clinical efficacy after minimally invasive puncture and drainage in the treatment of moderate basal ganglia cerebral hemorrhage underlying controlling the dosage of drugs in the elderly
Journal Title: Chinese Journal of Nervous and Mental Diseases - Year 2024, Vol 50, Issue 5
Abstract
[Objective] To investigate the effect of injection volume on clinical efficacy after minimally invasive puncture and drainage in the treatment of moderate basal ganglia cerebral hemorrhage underlying controlling the dosage of drugs in the elderly. [Methods] After successfully inserting the puncture needle into the center point in the largest layer long axis, the liquid hematoma was aspirated, and 40,000 units urokinase was injected into the hematoma cavity twice a day(2 mL in the small volume Group (SG), and 4 mL in the large volume group(LG), respectively). The needle were then adjusted and removed according to the hematoma clearance. The clearance rate of hematoma, intracranial pressure, edema volume, mortality, incidence of complications, neurological deficit score (NDS) and activities of daily living (ADL) were compared and analyzed. [Results] There were no significant differences in the first hematoma clearance rate, postoperative ICP and mortality between the two groups (P>0.05). Comparing to the SG, there was a relative higher postoperative hematoma clearance rate and lower volume of perihematoma edema in the LG (P < 0.05). Meanwhile, the needle retention time, urokinase usage and cumulative complications at 28 days after operation were lower than in the SG( P<0.05). For two parameters representing long-term outcome, the NDS and ADL scores were much better in LG than in SG (P<0.05). [Conclusion] Large volume injection can effectively drain the hematoma, shorten the needle retention time, reduce the usage of urokinase, decrease the incidence of postoperative complications and improve the prognosis of patients, thereby providing effective and safe method in treating moderate basal ganglia cerebral hemorrhage in the elderly.
Authors and Affiliations
Liang WANG, Wei DONG, Lian ZHENG, Jinmiao ZHANG, Ding YUAN, Guo. CHENG
Keywords
Related Articles
- EP ID EP750500
- DOI 10.3969/j.issn.1002-0152.2024.05.003
- Views 53
- Downloads 0
The cross-lagged panel network analysis of bullying and psychopathological symptoms among adolescents
[Objective] To explore the bi-directional dynamic associations of bullying perpetration and victimisation with psychopathological symptoms in children and adolescents. [Methods] The Adolescent Brain Cognitive Development...
Recommendations on clinical application of deutetrabenazine for treatment of tardive dyskinesia
Deutetrabenazine (DTBZ) is a selective oral small molecule inhibitor of vesicular monoamine transporter 2 (VMAT2). Its pharmacological action works by inhibiting VMAT2, thereby reducing the release of presynaptic dopamin...
Optimizing multi-domain hematologic biomarkers and clinical features for the differential diagnosis of unipolar depression and bipolar depression
[Objective] This study aims to build a differential diagnosis model for unipolar and bipolar depression based on clinical features and blood indicators. [Methods] According to inclusion and exclusion criteria, participan...
Clinical study about ictal facial dystonia of medial temporal lobe epilepsy
[Objective] To study the clinical and electrophysiological characteristics about ictal facial dystonia of medial temporal lobe epilepsy. [Method] Data was collected from patients with mesial temporal lobe epilepsy origin...
Research progress on multiple mechanisms underlying visual hallucinations in schizophrenia patients
Visual hallucination (VH) is a common symptom of schizophrenia, the underlying mechanism has not been fully elucidated. It has been found that the dysfunction of dopamine (DA) system, the overactivation of α-amino-3-hydr...