Effect of Intra-Uterine Growth Retardation on Umbilical Cord Blood Thyroid Hormone Level
Journal Title: Journal of Physiology and Pharmacology Advances - Year 2012, Vol 2, Issue 7
Abstract
The present endeavor is an attempt to see the influence of IUGR on umbilical cord plasma thyroid hormone level in order to sort out some ideas about the far-reaching consequence of growth retardation on the development of thyroid diseases in adult life. A group of 80 term babies delivered by normal vaginal delivery from eu-thyroid mothers was selected from a tertiary care teaching hospital and categorized into case (Term babies with birth weight ≤ 2 kg, n=40) and control (Term babies with birth weight ≥ 2.5 kg, n=40). Additional 17 term babies having birth weight ranging from 2.01 kg to 2.5 kg were made a separate group and were taken into account when correlation of birth weight with thyroid hormone status was studied. Serum TSH, total T3, total T4 level was measured by Micro plate immuno-enzymatic assay and serum glucose by GOD/POD technique. The collected data was analyzed with SPPSS (version 13) statistical package using t-test. The whole 97 babies were again divided in 4 different groups with a group mean birth-weight of 1.29, 1.8, 2.3 and 3.89 kg respectively. Serum TSH, total T3, total T4 and serum glucose levels were compared among these four groups in order to study correlation between the thyroid hormone status and degree of growth retardation. The collected data was analyzed by ANNOVA test. IUGR is associated with low umbilical cord serum total T4 level. The low the birth weight of the babies the lower will be the serum total T4 level, whereas serum TSH and serum total T3 showed no correlation with birth weight. There is also significant reduction of cord plasma glucose level in SGA babies as compared to AGA babies. Term SGA babies showed isolated reduction in cord plasma Total T4 level with little or no change in cord plasma TSH level. This ‟sub-clinical hypothyroidism‟ in term SGA babies highlights an altered Hypothalamo-Pituitary-Thyroid axis in IUGR.
Authors and Affiliations
S. Mukherjee , G. Chaudhuri , R. Bal
Keywords
Related Articles
- EP ID EP120527
- DOI -
- Views 113
- Downloads 0
A Case Control Study to Assess Impact of Risk Factors on Trends of Lung Cancer
Lung cancer is a leading cause of death with changing trends of occurrence, detection and treatment. The objective of this research was to identify impact of risk factors on changing trends of lung cancer in a case contr...
Thiol Containing Redox System and Blood Serum Inhibitory Properties Regarding IGM Antibodies from the Viewpoint of Pathophysiology: a Review
Redox system is a complex multi-level system. Various factors are involved in the regulation of its activity. Normally the system tends to the state of equilibrium. It is important to consider the balance mechanisms in t...
The Combined Effect of Injectable Recombinant Erythropoietin and Oral Iron on the Hematopoiesis of Extremely Overweight Neonates
Erythropoietin is the major regulating blood flow hormone which can be effect on hematopoiesis of premature infants. The aim of this study was to examine the effectiveness of intravenous recombinant erythropoietin regime...
Do CB1 Cannabinoid Receptors Regulate Insulin Signalling in Rat Primary Skeletal Muscle Cells?
The purpose of this study was to investigate the expression and signalling of CB1 cannabinoid receptors and the impact of CB1 activation and inhibition upon insulin signalling in rat primary skeletal muscle cells. QRT-PC...
Decrease Effect of Vitis Vinifera Leave Hydro-Alcoholic Extract on Reproductive Parameters In Adult Normal Male Rats
Grape leaves are used in a traditional food and for treatment of diarrhea, bleeding; and also reported that administered grape was good to treatment of constipation, gout and etc. So, the aim of this study was to investi...