Effect of long-term treatment with an inhaled corticosteroid (budesonide) on airway hyper responsiveness and clinical asthma in nonsteroid-dependent asthma in children
Journal Title: Medpulse International Journal of Pediatrics - Year 2018, Vol 7, Issue 2
Abstract
Several short-term studies have shown that inhaled steroids can reduce airway hyper responsive in asthma. To evaluate whether prolonged treatment can bring about full recovery, this double blind, randomized, control trial by systematically examined the effect of budesonide, 400 µg daily for 1 yr. on the airway hyper responsiveness over a period of 6 yrs. The time course and characteristics of improvements and associated changes in clinical asthma severity were also paralelly evaluated. Sixty two stable asthmatics, requiring bronchodilators alone, were selected for study. Monthly study of airway-responsiveness severity of clinical asthma was assessed by questionnaire by daily bronchodilator use, and by number of asthmatic exacerbations. Patients receiving budesonide showed a fourfold mean improvement in airway responsiveness compared with those receiving placebo (p < 0.005), whose responsiveness remained very stable. Sixty of the budesonide subjects improved and returned to the normal. Largest improvements occurred during the first 4 months but, in some progress was continued for one year. Impovements in responsiveness were accompanied by significant improvements in asthma symptoms, bronchodilator use, and number of asthma-exacerbations. The results show that regular, prolonged use of inhaled steroid can produce remarkable improvements in airway hyperresponsiveness, sometimes with a full remission. These improvement are accompanied by clinically significant improvements in clinical childhood asthma.
Authors and Affiliations
Akhilesh Bisaria, R E Bhingare, Pipliwal N
Keywords
Related Articles
- EP ID EP445072
- DOI 10.26611/1014721
- Views 234
- Downloads 0
Reliability and validity of clinical signs for anemia detection in school children
Anemia is widely prevalent in developing world and also is a public health challenge in India. It is a serious concern because it can result in impaired cognitive performance, behavioural and motor development, coordinat...
Impact of mobile phone use among children in an area in Rangareddy, Telangana
Background: 69 per cent of children surveyed across the eight countries use a mobile phone. Among 15 and 16-yearolds surveyed, 10 and 12 years were the most common ages to first receive a mobile phone. Objectives: To kno...
Comparison and correlation between serum bilirubin and transcutaneous bilirubin in NICU Bidar
Background: Hyperbilirubinemia is one of the most common problem in neonates. An estimation of the bilirubin value is essential for decision making in jaundiced babies. Transcutaneous bilirubin screening is a quick, non...
Early onset neonatal sepsis in relation to prolonged rupture of membranes of more than 18 hours - A prospective study
Background: Sepsis is the commonest cause of neonatal mortality globally and is responsible for about 3–50% of the total neonatal deaths in the developing countries. In India, sepsis contributes up to 52% of neonatal dea...
Role of serum zinc levels in simple febrile convulsions in children
Background: Febrile convulsions in children can be induced by several factors. In febrile convulsions there is an enhanced neuronal excitability during the normal brain maturation. Gamma amino butyric acid is an importan...