EFFECT OF MICROCYTIC ANAEMIA ON GLYCATED HAEMOGLOBIN (HbA1C) IN NON-DIABETIC ADULTS
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2017, Vol 6, Issue 69
Abstract
BACKGROUND Glycated haemoglobin (HbA1c) is used as a gold standard for monitoring glycaemic control of patients and is used as a predictor of diabetes–related complications. The HbA1c fraction is abnormally elevated in chronic hyperglycaemic states, like diabetes mellitus and it correlates positively with the glycaemic as well as metabolic control. Conditions that affect erythrocyte turnover affect HbA1c levels. The aim of this study was to determine the effect of microcytic anaemia on the HbA1c levels in non-diabetic patients, so as to analyse whether microcytic anaemia influences the HbA1c levels. MATERIALS AND METHODS A descriptive comparative study with a convenient sample size of 100 non-diabetic, anaemic patients and 100 age-matched nondiabetic non–anaemic controls were chosen. The patients who had glucose tolerance abnormalities (Impaired glucose tolerance or diabetes mellitus), blood loss, haemoglobinopathies, haemolytic anaemia, infestation, chronic alcohol ingestion and chronic liver or renal failure were excluded from the study. Relation of HbA1c with MCV was calculated using Chi square test. And also, HbA1c levels were compared between both the groups and analysed using independent t-test and its correlation with microcytic anaemia was calculated. RESULTS The mean HbA1c level of the non-diabetic patients with microcytic anaemia (6.89 ± 0.55 %) was higher than that in the non– anaemic controls (5.35 ± 0.28 %) (p< 0.001). CONCLUSION Microcytic anaemia definitely has an impact on the HbA1c levels. In patients with microcytic anaemia, as the MCV decreases, the values of HbA1c tends to rise spuriously, probably because, the glycation of the globin chain, in the relative absence of iron would occur more readily.
Authors and Affiliations
Gokhularaj Baskar, Sundaramurthy Ganesan, Karthigeyan Thanjavur Sethuraman, Ramesh Bhaskaran
Keywords
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- EP ID EP233248
- DOI 10.14260/Jemds/2017/1072
- Views 98
- Downloads 0
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