Effect of non-absorbable antibiotic, rifaximin in patients with irritable bowel syndrome: A single-center randomized controlled study
Journal Title: National Journal of Physiology, Pharmacy and Pharmacology - Year 2018, Vol 8, Issue 6
Abstract
Background: Irritable bowel syndrome (IBS), most common functional bowel disease, does not have a definite treatment. Studies revealed the involvement of bacterial overgrowth for its pathology. The aim of this study is to evaluate the effect of a non-absorbable antibiotic. Aims and Objectives: The primary objective of the study is to assess the efficacy of a 14 days course of oral rifaximin at 400 mg thrice daily in patients with IBS without constipation. The secondary objective of this study is to evaluate the safety of a 14 days course of rifaximin at 400 mg thrice daily as compared with placebo in patients with IBS without constipation. Materials and Methods: In this single-center, randomized, placebo-controlled study, we recruited patients, using Rome III criteria in 2 years. Treatment group received rifaximin 400 mg thrice daily for 2 weeks. All patients underwent symptom assessment and safety assessment before inclusion, at the end of the treatment and 1 week after the regimen. Primary endpoint (proportion of patients who achieved adequate relief of IBS symptoms) and Likert scales of symptoms of both groups were compared. Results: Proportion of subject, who achieved adequate relief of IBS symptoms in the rifaximin arm, is more than placebo (68% vs. 39.1%). At the end of 2 weeks therapy, both groups show significant improvement in bloating score (P < 0.002), pain score (P < 0.001), and overall score (P < 0.002) and it continued for 1 more week. There were no significant adverse effects reported. Conclusion: A 2 weeks course of 400 mg rifaximin thrice daily regimen provided a significant improvement in global IBS symptoms.
Authors and Affiliations
Bhagyalekshmi N, Ramesh M, Prathibha V K, Xavier Ignatius J
Keywords
Related Articles
- EP ID EP490385
- DOI 10.5455/njppp.2018.8.1246807022018
- Views 172
- Downloads 0
Study of potential drug–drug interaction between prescribed drugs in patients attending outpatient department of medicine at tertiary-care hospital in south Gujarat region
Background: Drug–drug interactions (DDIs) are very common and responsible for 6%–30% of the adverse drug events that will increase healthcare cost and patient outcome. Polypharmacy significantly contributes to DDI...
Anti-inflammatory activity of lisinopril in albino rats
Background: Angiotensin II (Ang II) is a product of renin angiotensin aldosterone system. Angiotensin-II regulates vascular tone, stimulates the release of pro-inflammatory cytokines, activates nuclear factor-kappa B, in...
Influence of menopause on cardiovascular responses to behavioral stressors: A comparative study
Background: There is increased cardiovascular morbidity and mortality in post-menopausal women as compared to pre-menopausal women. There is an altered autonomic control with a shift toward sympathetic hyperactivity in m...
A histological study of alloxan-induced diabetes on experimental male Wistar rats
Background: Alloxan is a toxic chemical which is used for induction of diabetes in experimental animals. In the light of various earlier researches which showed different dosages for induction, it has been decided to sel...
Synthesis of some new 1,3,4-oxadiazole derivatives bearing sugars and α-aminophosphonate derived from 4-nitrophenol as anticancer agents
Background: 1,3,4-oxadiazoles square measure a very important category of heterocyclic compounds with a broad variety of biological activities such as medicament, analgesic, ulcerogenicity, apoptosis inducer, anti-mycoba...