Effect of oral administration of probiotics on intestinal colonization with drug-resistant bacteria in preterm infants
Journal Title: Paediatrica Indonesiana - Year 2017, Vol 57, Issue 2
Abstract
Background Oral administration of probiotics in newborn preterm infants has been shown to be helpful, especially ın reducıng the incidence of necrotizing enterocolitis and overall mortality rates.Objective To evaluate the effect of probıotıc supplementation on ıntestınal colonization by antibiotic-resistant microorganisms in preterm infants receiving antibiotics in a neonatal intensive care unit (NICU).Methods The prospective, randomized trial was performed ın preterm infants who were hospitalized in the NICU at Baskent University Ankara Hospital between January 2011 and February 2012. A total of 51 infants were enrolled and randomly assigned to one of two groups: Group 1 (n=27) received probiotic therapy and Group 2 (n=24) did not receive probiotics. The probiotic used was Lactobacillus reuteri (Biogaia® AB, Sweden). Subjects underwent weekly nasal swab and stool cultures for a maxımum of 6 weeks, and at the tıme of dıscharge ıf thıs was prıor to 6 weeks. All posıtıve cultures were further tested for culture-specıfıc ıdentıfıcatıon and antıbıotıc suceptibility.Results A total of 607 cultures were evaluated. Posıtıve cultures were found ın 37.9% from Group 1 and 35.2% from Group 2. Intestınal colonızatıon by antıbıotıc-resıstant bacterıa dıd not sıgnıfıcantly dıffer between groups (P>0.05). Conclusions Oral supplementation with probiotics do not prevent the intestınal colonization of antibiotic-resistant microorganisms in preterm NICU patıents who receıved antıbıotıc treatment.
Authors and Affiliations
Abdullah Kurt, Deniz Ince, Ayşe Ecevit, Özlem Azap, Zafer Ecevit, Ersin Öğüş, Ali Ulaş Tuğcu, Aylin Tarcan
Agreement between the Denver II and Parents’ Evaluation of Developmental Status tests, with and without the assistance of a table of categorical responses
Background Among standardized developmental screening tools, the Denver II is commonly used by Indonesian pediatricians, but the Parent’s Evaluation of Developmental Status (PEDS) test has gained in popularity. The Denve...
Forced expiratory volume in 1-second and blood gas analysis in children during asthma attacks
Background Asthma is the most common chronic disease in the world, with a high incidence in children. Blood gas analysis and pulmonary function test using spirometry are recommended to evaluate the degree of asthma in ch...
Comparison of urine neutrophil gelatinase-associated lipocalin to serum creatinine to assess kidney function in neonatal asphyxia
Background Infants with neonatal asphyxia have multiorgan damage, such as to the kidneys (50%), central nervous system (28%), cardiovascular system (25%), and lungs (23%). Neonatal asphyxia reduces kidney perfusion, ofte...
Perinatal factors associated with autistic spectrum disorder
Background The prevalence of autistic spectrum disorder(ASD) has increased in recent decades. The definitive causesof ASD have yet to be recognized. Howevei; it is believed thatboth genetic and non-genetic, as well as pe...
Lactate clearance as a predictor of mortality in neonatal sepsis
Background Neonatal sepsis remains the leading cause of neonatal deaths. Therefore, efforts should be made to reduce its mortality. Lactate clearance can be used as a marker of onset of hypoxia and microcirculation disor...