EFFECT OF OREXIN DRUG AND SOME MINERALS ON RATS EXPOSED TO OBESITY AND ALZHEIMER DISEASE
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2017, Vol 6, Issue 1
Abstract
The affect of administration of some minerals on rats exposed to obesity and Alzheimer disease was studied. Thirty rats of Sprague Dawley (weighting 200±10 g) were divided into sex groups (5 rats). One group considered as normal control group. Twenty five rats were fed on the high fat diet and administered aluminum chloride for 6 weeks to induce obesity and Alzheimer The obese with Alzheimer's rats were classified into positive control, orexin (20 mg/kg b.w / i.m), iron (100 mg/kg b.w), calcium (6 g/kg b.w) and zinc (18 mg/kg b.w) by stomach tube groups. The results revealed that there was a significant decrease in body weight gain, weight gain percent and FER among all rats group which treated with orexin, calcium, iron and zinc in comparing with non- treated obese male and Alzheimer's rats positive control group. Moreover, The treatment rat groups showed significant decrease in serum cholesterol (CHO), triglyceride (TG), low density lipoprotein cholesterol (LDLc), very low density lipoprotein cholesterol (VLDLc) and total lipids (T. Lipids) and also decrease in atherogenic indexes but showed significant increase in serum high density lipoprotein cholesterol (HDLc), iron and zinc in comparing with non-treated positive rat group. However, These rat groups showed a significant increase in brain catalase (CAT), glutathione-S- transferase (GST) and superoxide dismutase (SOD) but a significant decrease in brain levels of malondialdehyde (MDA) level and B-amyloid compared to positive control group. These biochemical changes were accompanied with histopathological alterations in brain tissue. It is concluded that the treatment with minerals could ameliorate most of the evaluated biochemical parameters and improve the induced degenerative histopathological changes.
Authors and Affiliations
Abd El-Ghany M. A.
Keywords
Related Articles
- EP ID EP616981
- DOI -
- Views 240
- Downloads 0
PREVALENCE OF TINEA CAPITIS AMONG PRIMARY SCHOOL PUPILS IN OVOM-AMA-ASAA, ABIA STATE, NIGERIA
Tinea capitis is a dermatophytic infection of the scalp and scalp hair. It is a public health problem among prepubetal or primary school children. This study was thus, carried out to determine the prevalence of tinea cap...
PHYTOCHEMICAL SCREENING, ANTIMICROBIAL EVALUATION AND GC-MS ANALYSIS OF CYPERUS ROTUNDUS
Cyperus rotundus L. commonly called nut grass is a highly potent traditional herbal drug used for the treatment of a number of ailments. The present study was aimed to evaluate the antimicrobial activity as well as deter...
PEPTIDE-OLIGO CONJUGATES TARGETING RAS AND CYCLIN B1: DESIGN AND AN IN VITRO EVALUATION
Background: cancer is the second leading cause of death worldwide. Peptide-oligo conjugates (POC) are certain molecules that can be used as multifunctional therapeutics. Aim: designing POC targeting both Ras family of pr...
ANTIHYPERGLYCEMIC, ANTIHYPERLIPIDEMIC EFFECTS OF ETHANOL EXTRACT OF NIGELLA SATIVA SEEDS IN STREPTOZOCIN / HIGH FAT DIET INDUCED HYPERGLYCEMIC MICE
Objective: The present study was designed to determine the antihyperglycemic and antihyperlipidemic effect of ethanol extract of Nigella sativa seeds, in Streptozocin/high fat diet induced hyperglycemic mice. Materials a...
LITERARY REVIEW ON PARPATI KALPANAS
Parpati kalpanas are important preparations which are mentioned in Rasashastra texts like Rasatarangini, Yogaratnakara etc. These preparations are used in treating Grahani, Prameha & other vyadhies. Parpati kalpanas are...