Effect of Phencyclidine Derivatives on Anxiety-like Behavior Using an Elevated-plus Maze Test in Mice
Journal Title: Advances in Clinical and Experimental Medicine - Year 2012, Vol 21, Issue 3
Abstract
[b]Abstract [/b] [b]Objectives. [/b]The study attempted to investigate the anti-anxiety activities of Phencyclidine (1-(1-phenylcyclohexyl) piperidine, PCP, I) and some of its derivatives (M, F, L, B, S, P) with the elevated-plus maze (EPM) Test. [b]Material and Methods.[/b] Phencyclidine and its derivatives (M, F, L, B, S, P) were administrated intraperitoneally (i.p.) at a dose of 10 mg/kg to male mice. Anxiety-like behaviors were assessed using the elevated-plus maze test. [b]Results.[/b] EPM results revealed an increase in open arms time spent after applying PCP and M, L, P, and B compounds at the administered dosage. Moreover, an increase in the number of open arm entries was observed with M, P, and B compounds. The P, B and S compounds increased the locomotion of animals, too, which might be considered as the side effect to the compounds. [b]Conclusions.[/b] Considering the elevated-plus maze results, it was concluded that M and L compounds could be considered as a potential anxiolytic with less side effects due to a probable high electron donation of the methoxy group, as well as the hydrophilic properties of hydroxyl groups on these compounds.
Authors and Affiliations
Ramin Hajikhani, Abbas Ahmadi, Nima Naderi, Kayvan Yaghoobi, Zahra Shirazizand, Nazereh Rezaee, Babak Niknafs
Keywords
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