EFFECT OF POMEGRANATE (PUNICAGRANATUM L.) (ARILS, PEELS AND SEEDS) EXTRACTS ON FATTY LIVER IN RATS
Journal Title: World Journal of Pharmaceutical Research - Year 2019, Vol 8, Issue 1
Abstract
Objectives: This study aimed to investigate the ameliorative effect of pomegranate extracts (arils, peels, and seeds) on nonalcoholic fatty liver disease in rats. Methods: The nonalcoholic fatty liver disease was induced by methionine choline deficient (MCD) diet. Different pomegranate extracts (arils, peels, and seeds) were administered orally at dose 5ml/kg/b.wt./day. Rats were divided into 2 groups. Group I healthy group were fed on standard diet and group II fatty liver group were fed on MCD diet. After a month of the experiment, Group I was subdivided into 4 groups as follows: G1 healthy control, G 2 pomegranate juice (healthy PJ), G 3 pomegranate peels extract (healthy PPE), and group 4 pomegranate seeds extract (healthy PSE). Also Group II was subdivided into 4 groups included: G5 (fatty liver control group), G6(fatty liver + PJ), G7(fatty liver + PPE) and G8(fatty liver + PSE). Results: The results indicated that MCD diet induced significantly hyperlipidemia, significantly elevated nitric oxide concentration and malondialdehyde level, and also significantly depletes reduced glutathione content, catalase, paraoxonase and arylesterase enzymes activities in liver. Moreover MCD diet significantly raised plasma pentaxin-3 and cytokeratin-18 concentrations and significantly elevated liver enzymes. However pomegranate extracts (PJ, PPE and PSE) significantly reduced hyperlipidemia, significantly depleted the elevation of oxidative stress markers and also significantly raised the antioxidants. Moreover, pomegranate extracts improved the liver function and significantly depleted markers for cell death. The results were confirmed by liver histopathology In conclusion: Pomegranate extracts administration attenuated the severity of nonalcoholic fatty liver disease in rats.
Authors and Affiliations
Prof. Dr. Gehan Salah El- Din Moram
Keywords
Related Articles
- EP ID EP666874
- DOI -
- Views 170
- Downloads 0
THE APPROVAL OF DRUG PROCESS: A REVIEW
It takes on average 12 years and over US$350 million to get a new drug from the laboratory onto the pharmacy shelf. Once a company develops a drug, it undergoes around three and a half years of laboratory testing, before...
ISSUES RELATED TO NUTRITION IN PREGNENAT WOMEN
During pregnancy nutrition related problem is the one of the most common problem. Because most of the rural womans are lacking awareness about the consumption of adequate nutrition during pregnancy in mother compared to...
CORRELATION OF REGULATORY AFFAIRS OFFICER WITH DIFFERENT DEPARTMENT OF PHARMACEUTICAL INDUSTRY IN INDIA AND IMPACT OF GST
Drug Regulatory Affair (DRA) is an important part of the organizational structure of Pharmaceutical companies. Now days it’s necessary to have DRA department in companies for fast growth and development of the company. T...
GREEN SYNTHESIS OF SILVER NANOPARTICLES VIA MEDICINAL PLANT EXTRACTS AND THEIR ANTIBACTERIAL ACTIVITIES
The green synthesis of silver nanoparticles (Ag NPs) were studied by bio reduction of silver nitrate solution using extractions of three commonly available medicinal plants found in Sri Lanka. Extractions were prepared u...
EFFECTIVENESS OF PLANNED TEACHING PROGRAMME ON KNOWLEDGE REGARDING MANAGEMENT OF PREGNANCY INDUCED HYPERTENSION
The study was conducted with the aim to improve the knowledge of pregnant women regarding Management of pregnancy induced hypertension, thereby prevent the occurrence of pregnancy induced hypertension among women and red...