Effect of Radiotherapy on Oxidative Stress and Serum Adenosine Deaminase Levels in Carcinoma Cervix Patients
Journal Title: Journal of Medical Science And clinical Research - Year 2015, Vol 3, Issue 2
Abstract
Carcinoma cervix is the most prevalent genital tract cancers in the world including India. Low levels of antioxidants induce the generation of free radicals leading to DNA damage and further mutations. Alterations in enzyme levels like adenosine deaminase (ADA), an enzyme of the purine salvage pathway, has been found to be elevated in various malignancies. The present study was done to evaluate the oxidative stress & adenosine deaminase (ADA) levels in carcinoma cervix(CaCx) patients. Malondialdehyde(MDA), glutathiones-transferase(GST) & adenosine deaminase(ADA) levels were estimated before and after radiotherapy with Cobalt 60(Co60) in 20 patients. They were compared with age and sex matched healthy controls. Significantly increased levels of MDA (p<0.001) was observed, whereas the activity of GST (p<0.001) and ADA (p<0.05) were significantly decreased in CaCx patients as compared with healthy controls. Upon radiotherapy a significant reduction in MDA levels, with a significant increase in GST levels was observed. Though ADA levels were found to be increased after radiotherapy it is not significant. Thus it may be concluded that oxidative stress is present among CaCx patients, and radiotherapy was found to decrease the oxidative stress in CaCx patients..
Authors and Affiliations
Dr. Vasundhara Devi. I.
Keywords
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