Effect of Root and Leaf Extracts of Tetracarpidium conophorum on Liver Enzyme Levels in Alloxan Induced Diabetic Rats
Journal Title: Journal of Pharmaceutical Research International - Year 2015, Vol 5, Issue 4
Abstract
Aim: Tetracarpidium conophorum is a climbing shrub grown principally for its leaf, root, fruit and nut in Southern Nigeria and Western Cameroon. This study was conducted to assess the liver function status in alloxan- induced diabetic rats treated with methanol extracts of leaf and root of Tetracarpidium conophorum. Methodology: The leaf and root extracts of Tetracarpidium conophorum were obtained using Soxhlet extractor and diabetes was induced by intraperitoneal injection of alloxan (100mg/kg). Plasma levels of glucose, alkaline phosphatase (ALP), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were estimated using standard diagnostic kits and procedures. Results: The results from this study show significant (P<0.001) elevation of ALP, AST and ALT levels in alloxan- induced diabetic rats. Oral administration of leaf and root extracts of Tetracarpidium conophorum for 14 days significantly (P<0.001) lowered diabetic induced serum liver enzyme levels. Conclusion: The present results indicate that the leaf and root extracts of Tetracarpidium conophorum possess potent antidiabetic and hepatoprotective activities and could be exploited in the development of antidiabetic and hepatoprotective drugs.
Authors and Affiliations
Ogbonna Onyemaechi John, Udia Pius Monday, Ikechi Winifred Nneka, Ogbeihe Geraldine Ogom, Omoregha Charles Uwaifiokun, Nnaemeka Louis Benedict
Keywords
Related Articles
- EP ID EP344757
- DOI 10.9734/BJPR/2015/13407
- Views 113
- Downloads 0
Primary Unresponsiveness to Pioglitazone is not Related to PPAR-ϒ and Its Co-activator Gene Exon SNP Markers
The objective of this prospective observational study was to assess inter-individual variations in lipid and glycemic response to pioglitazone (30 mg OD) and their predictors in newly diagnosed T2DM patients. Out of 104...
Rumex usambarensis (Dammer) Leaf and Stem Extract Effect on Body Weight and Lipid Profile: A Study in Albino Rats
Aims: The aim of the study was to determine the effect of Rumex usambarensis plant extract on body weight and lipid profile of fattened albino rats. Study Design: This was an in-vivo experimental study in laboratory ani...
Densitometric and Spectrometric Determinations of Florfenicol and Buparvaquone
Three new accurate and sensitive methods were developed for the determination of two veterinary drugs. Florfenicol was analyzed by a stability-indicating TLC/densitometric method in presence of its amine degradation prod...
Effect of Ethyl Acetate Extracts from Peel of Citrus decumana and Citrus aurantifolia on Aspirin Induced Gastric Ulcer in Mice
Aims: The present study is aimed at investigating the antiulcer activity of ethyl acetate extract of Citrus decumana (grapefruit) and Citrus aurantifolia (lime) peels. Study Design: Animals were divided into six groups o...
Diclofenac-induced Gastric Ulceration in Rats: Protective Roles of Pantoprazole and Misoprostol
Gastrointestinal damage caused by diclofenac remains a significant clinical problem. Pantoprazole provides potent and long-lasting inhibition of gastric acid secretion and has proven efficacy in healing diclofenac-associ...