Effect of Short Term Administration of Diazepam and Bromazepam on Lipid Profile of Albino Wistar Rats (Rattus rattus)
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2018, Vol 6, Issue 3
Abstract
Abstract: Diazepam and bromazepam though are restricted drugs are commonly used especially in this part of the world; it is a known fact that some medications has negative effect on lipid profile. The aim of this study is to investigate the effect of short term administration these drugs on albino wistar rats. This study investigated the in-vivo effect of short term administration of diazepam (DZ) and bromazepam (BZ) at 0.0046 mg/100 g bwt (1), 0.0036 mg/100 g bwt (2), 0.0026 mg/100 g bwt (3) and 0.0016 mg/100 g bwt (4) concentrations on serum lipid profile of albino wistar rats. The parameters that were investigated are: total cholesterol, triglyceride, high density lipoprotein (HDL) and low density lipoprotein (LDL). Data obtained were subjected to statistical calculation using SPSS version 18. Mean values (M) ± SD were calculated and One-Way ANOVA test was performed, significance level was calculated at 95 % confidence level (P ˂ 0.05). Serum HDL, serum LDL, serum total cholesterol, and serum triglyceride were reduced by both drugs throughout the duration of study in a dose-dependent manner. The reduction was significant (P < 0.05) for total cholesterol and triglyceride. Comparing the reducing/increasing effect between the two drugs at similar dosage showed no significant difference. Short term administration of diazepam and bromazepam at these low dosages does not affect negatively total cholesterol, triglyceride, HDL and LDL concentrations.
Authors and Affiliations
Nzor, Joyce N
Keywords
Related Articles
- EP ID EP474699
- DOI -
- Views 77
- Downloads 0
Microbiological Stydy of Diarrhoeal Patients Admitted in Tertiary Hospital of Telangana
Acute diarrhoeal illness is common in tropical regions during summer and monsoon seasons microbial agents causing diarrhea can be bacteria, virus, parasite or fungus. Our aim was to study the microbiological agents invol...
Symbolic Case of a DiffueChorangiomatosis without Foetal Impact with a Review of the Literature
Most of the macroscopically visible abnormalities of the placenta are of no functional significance, the major exception to this general banality being the uncommon large haemangioma or diffuse chorangiomatosis which can...
Study of factors associated with success of vaginal birth after previous one caesarean section
To study the factors associated with vaginal birth after one cesarean section, to evaluate fetal and maternal outcome in VBAC deliveries, It is a case control prospective study conducted in department of Obstetrics & Gyn...
To Study the Effect of Pre-Emptive Doses of Gabapentin for Postoperative Analgesia in Patients Undergoing Surgery under General Anaesthesia
Abstract: Postoperative period is very crucial from recovery point of view. For fast and smooth recovery, postoperative period should be free of complications especially pain. Multimodal analgesia is quite effective and...
Epidemiology, Comorbidities and Clinical Features of Gout in Southern Part of India.
Gout is a common painful inflammatory arthritis. Both the incidence and prevalence of gout have increased worldwide in recent years and the clinical pattern of gout is becoming more complex. Gout is typically diagnosi...