EFFECT OF SUPPLEMENTATION OF VITAMIN E, VITAMIN C AND REDUCED GLUTATHIONE ON COPPER ION INDUCED LIPOPROTEIN OXIDATION IN RENAL DISEASED PATIENTS – AN IN VITRO STUDY
Journal Title: Indian Journal of Clinical Biochemistry - Year 2006, Vol 21, Issue 1
Abstract
The oxidative modification of lipoprotein especially low density lipoprotein (LDL) plays a key role in the initiation and progression of atherosclerosis. Serum apolipoproteinB (apoB) level is found to be an important marker for atherosclerosis. The present paper focuses on the measurement of serum apoB levels and the effect of Vitamin E, Vitamin C and reduced glutathione on the copper ion induced oxidation of LDL + VLDL (VLDL-Very Low Density Lipoprotein) lipoprotein fraction isolated from the serum of chronic renal failure (CRF) and renal transplanted patients. The level of apoB is significantly higher in the serum of transplanted patients when compared to CRF patients and normal subjects. The level of TBARS formed in oxidized LDL + VLDL lipoprotein fraction of CRF and renal transplanted patients are significantly increased than normal even in the presence of antioxidants but the level of TBARS produced with antioxidants is comparatively lesser than that produced by oxidized lipoprotein fraction without antioxidants. It may be concluded that oxidation of LDL can be prevented at an earlier stage by Vitamin E supplementation. The supplementation with Glutathione serves as the best method of preventing the lipoprotein oxidation among the renal diseased patients.
Authors and Affiliations
C. S. Parameswari , B. Vijayageetha , R. Vijayakumar
Keywords
Related Articles
- EP ID EP149574
- DOI -
- Views 94
- Downloads 0
BLOOD ZINC PROTOPORPHYRIN, SERUM TOTAL PROTEIN, AND TOTAL CHOLESTEROL LEVELS IN AUTOMOBILE WORKSHOP WORKERS IN RELATION TO LEAD TOXICITY: OUR EXPERIENCE
Blood zinc protoporphyrin (ZPP), serum total protein (TP), and total cholesterol (TC) levels in automobile workshop workers in relation to lead toxicity were analysed. In the present study, automobile workshop workers...
OXIDATIVE STRESS AND CALCIUM-PHOSPHORUS LEVELS IN RHEUMATOID ARTHRITIS
Generation of reactive oxygen species is an important factor in the development and maintenance of rheumatoid arthritis (RA) in humans. This study was undertaken to investigate interplay among oxidants, antioxidants and...
SERIAL COMPOSITION OF HUMAN MILK IN PRETERM AND TERM MOTHERS
Human milk samples were collected from 86 mothers included in the study on days 3, 7, 14 and 28 of lactation. The mothers were divided into three groups on the basis of gestation viz. group 1 : 37-41 weeks (n=41), grou...
ASSOCIATION OF PLASMA LEVEL OF THIOBARBITURIC ACID REACTIVE SUBSTANCES WITH EXTENT OF HEPATOCELLULAR INJURY IN PRETERM INFANTS WITH CHOLESTATIC JAUNDICE
The present study was designed to determine the association between extent of hepatocellular injury and plasma level of thiobarbituric acid reactive substances (TBARS) in pre term infants with cholestasis. Preterm infa...
PARAOXONASE ACTIVITY AND ANTIBODIES TO OXIDIZED-LDL IN CHRONIC RENAL FAILURE PATIENTS ON RENAL REPLACEMENT THERAPY
Serum paraoxonase (PON1) and antibodies to oxidized-LDL (anti ox-LDL) were measured in chronic renal failure subjects on renal replacement therapy such as hemodialysis (HD) peritoneal dialysis (PD) and transplantation...