EFFECT OF TELMISARTAN ON SERUM LIPID PROFILE IN PATIENTS WITH HYPERTENSION AND DYSLIPIDEMIA
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2013, Vol 2, Issue 4
Abstract
Background and Objectives: Hypertension and dyslipidemia are two major risk factors for cardiovascular disease and they commonly occur together. Management of dyslipidemia in a hypertensive patient significantly reduces the total cardiovascular risk .Telmisartan is an Angiotensin receptor blocker with a partial agonistic action on PPAR-ï§. In the present study, the effect of Telmisartan on serum Lipid Profile was evaluated in hypertensive patients who also have associated Dyslipidemia and also the efficacy of Telmisartan in reducing systolic and diastolic BP was assessed in these patients. Materials and Methods: A total of 50 outpatients from the medical outpatient department of Gandhi Hospital, Secunderabad, were enrolled into the study. These patients had grade І essential Hypertension and mild dyslipidemia. After the study period of 24 weeks, the efficacy of Telmisartan in reducing serum lipid profile was evaluated apart from its effect on reducing systolic and diastolic BP. Results: Telmisartan was very effective in reducing serum triglycerides (27 %↓, P<0.01), VLDL-C (27 %↓, P<0.01), LDL-C (22%↓, P<0.01). It also decreased serum cholesterol by 16% (P<0.01). HDL-C increased by 14% (P<0.05). Telmisartan in a dose of 40-80 mg/day, significantly reduced both systolic BP by 18 %( P<0.01) and diastolic BP by 12 %( P<0.01) Conclusion: In our study, Telmisartan proved to be effective not only in controlling BP, but had a favorable effect on lipid profile also So, in conclusion, all the patients with uncomplicated Hypertension and mild dyslipidemia can be effectively treated with Telmisartan.
Authors and Affiliations
Vanitha M| Department of Pharmacology, Osmania Medical College, Hyderabad Corresponding author email: hayavanitha@yahoo.in, Vijayal K| Department of Pharmacology, Dr VRK Women’s Medical College & Research Institute, Hyderabad
Keywords
Related Articles
- EP ID EP11051
- DOI 10.5958/j.2319-5886.2.4.119
- Views 385
- Downloads 21
Epidemiologic description and therapeutic outcomes of cutaneous leishmaniasis in Childhood in Isfahan, Iran (2011-2016)
Cutaneous leishmaniasis is a parasitic disease produced by Leishmania parasite and is transmitted by sandfly. The aim of this study was to investigating the epidemiology of Cutaneous leishmaniasis and different aspects...
CONCURRENT ORIGIN OF RIGHT GASTROEPIPLOIC AND LEFT COLIC ARTERIES FROM INFERIOR PANCREATICODUODENAL ARTERY: RARE VARIATION OF SPLANCHNIC ANASTOMOSIS
In the present case, inferior pancreaticoduodenal artery, the first branch of superior mesenteric artery, was exceptionally giving rise to right gastroepiploic artery and left colic artery simultaneously. Right gastroep...
SERUM LEVELS OF HIGH SENSITIVITY C REACTIVE PROTEIN AND MALONDIALDEHYDE IN CHRONIC KIDNEY DISEASE
Background: Chronic kidney disease cases are at increased risk for progression to end stage renal disease and accelerated atherosclerosis, with premature cardiovascular morbidity and mortality being the more frequent o...
Prioritization of the hemodialysis patients' preferences in acquisition of health information: A strategy for patient education
Full training according to the information needs of patients reduces health care costs and increases the quality of care. The present study was conducted aims to prioritize the preferences of hemodialysis patients in ac...
Effect of forced swim stress on wistar albino rats in various behavioral parameters
Introduction: Stress is an important factor of depression that causes the changes in various body systems. The forced swim test is a commonly used stressor test where rats are forced to swim in specially constructed ta...