EFFECT OF TROXERUTIN ON CARDIAC INSULIN SIGNALING IN HIGH FAT, HIGH FRUCTOSE DIET - INDUCED INSULIN RESISTANT MICE
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2014, Vol 5, Issue 10
Abstract
The present study investigates the effects of troxerutin (TX) on insulin signaling in the heart of high fat, high fructose diet (HFFD)-induced insulin resistant mice. Adult male Mus musculus mice of body weight 25–30 g were used for the study. HFFD was fed to animals to induce insulin resistance. On the 16th day a group of HFFD-fed mice were supplemented with TX (150 mg/Kg bw, p.o) till the end of the experimental period. Control mice fed control diet and TX-unsupplemented HFFD-fed mice were also maintained. Analyses were performed after 60 days in plasma and heart tissue of mice. HFFD-fed mice displayed higher levels of glucose and insulin, decreased tyrosine phosphorylation of insulin receptor-β (IR-β) and insulin receptor substrate-1 (IRS-1). The association of p85 subunit of phosphotidyl inositol 3 kinase (PI3K) with IRS-1, subsequent Akt phosphorylation and GLUT-4 translocation were reduced. TX treatment to HFFD-fed mice reduced hyperglycemia, hyperinsulinemia and enhanced tyrosine phosphorylation of IR-β, IRS-1, IRS-1-PI3K association, Akt and GLUT-4 activation. These findings suggest that TX activates IRS–PI3K–Akt pathway of insulin signaling and thereby promotes insulin action in the heart. Thus, TX could be a promising agent for the management of insulin resistance.
Authors and Affiliations
Geetha Rajagopalan , Venkatraman Carani
Keywords
Related Articles
- EP ID EP116384
- DOI 10.7897/2230-8407.0510164
- Views 117
- Downloads 0
FORMULATION AND EVALUATION OF IMMEDIATE RELEASE VENLAFAXINE HCL TABLETS: COMPARATIVE STUDY OF SUPER DISINTEGRANT AND DILUENTS
The objective of the present study was to formulate and evaluate immediate release Venlafaxine HCl tablets: comparative study of different superdisintegrants (croscarmellose sodium, crospovidone and sodium starch glycola...
CONTRAST ADVERSE EFFECT STUDY OF ASPIRIN AND CLOPIDOGREL IN STROKE PATIENTS USING COMBINATION AND INDIVIDUAL MEDICATION
Ischemia and hemorrhage are the conditions which may lead to stroke. As stroke is a medical emergency, treated with medications such as aspirin, clopidogrel and dipyridamole. In the present study the combination and indi...
A CLINICAL STUDY ON THE EFFICACY OF WHEAT GRASS JUICE IN PRAMEHA
It is a clinical study conducted on patients of Prameha (Madumeha) nearest resembling condition with diabetes mellitus, a rich man’s disease. Present study was planned with an aim and objectives. To evaluate the hypoglyc...
PHYTOESTROGENS IN CANCERS AND SOME OTHER DISORDERS
Phytoestrogens are natural plant compounds which have a similarity to human estrogens. They hold great potential for health benefits. Recent epidemiological studies have suggested that typical Asian diets, which have alw...
COMPUTATIONAL EVALUATION OF SPIROISOXAZOLINES AS INHIBITOR OF AChe
Spiroisoxazolines are structurally diverse group of compounds that show wide range of biological activity. The computational evaluation of the spiroisoxazolines derivatives as the acetylcholinesterase inhibitor was perfo...