Effect of two different doses of Dexmedetomidine on hemodynamic responses during tracheal extubation
Journal Title: Medpulse International Journal of Anesthesiology - Year 2018, Vol 8, Issue 3
Abstract
Background: Haemodynamic responses to tracheal extubation have always been of importance to the anaesthesiologist.Different concentrations of dexmedetomidine ranging from 0.25 µg/kg to 1.0 µg/kg intravenously as a bolus, have been studied for attenuation of pressor responses to extubation and intubation. Aim: To study the effects of two different doses of dexmedetomidine on hemodynamic responses during tracheal extubation. Material and Methods: A total of 66 patients undergoing surgery under general Anaesthesia in our hospital were randomly divided into 2 groups: Group-D1: Dexmedetomidine (0.25 µg/kg) group –33 patients; Group-D2: Dexmedetomidine (0.5 µg/kg) group – 33 patients. Results: The heart rate was significantly lower in D2 group at 10 minutes after starting of study drug, during extubation and till 15 minutes after extubation (p<0.05).The SBP and DBP was significantly lower in D2 group during extubation and till 15 minutes after extubation (p<0.05). Conclusion: Dexmedetomidine in 0.5 mcg/kg dose is optimum to attenuate the extubation response as compared to low dose i.e., 0.25 mcg/kg.
Authors and Affiliations
Pradeep Shivaji Raut, Ghanshyam Jadhav
Keywords
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- EP ID EP453352
- DOI 10.26611/1015839
- Views 158
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