Effect of Urate-Lowering Therapy on Gout and Related Comorbidities – A Retrospective Study of 200 Patients
Journal Title: Journal of Bone and Joint Diseases - Year 2018, Vol 0, Issue 0
Abstract
Introduction: There is an increasing prevalence of hyperuricemia and gout worldwide. A substantial body of epidemiological and experimental evidence suggests that serum uric acid (sUA) is an important, independent risk factor for cardiovascular disease (CVD) and chronic kidney disease, especially in patients with hypertension (HTN), heart failure, or Type II diabetes mellitus. Materials and Methods: 200 patients with diagnosis of gout, with at least 3 years of follow-up were reviewed. They were divided into 2 groups; 60 patients with mean sUA level (sUA) <6 mg/dL and 140 patients with mean sUA ≥6 mg/dL. Results: e long-term urate-lowering therapy maintaining the serum urate level under 6 mg/dL leads to significant decrease in the incidence of gout-related comorbidities. Conclusion: There exists an association between gout and subsequent CVD and HTN. Retaining control of uric acid decreases the incidence of acute gouty attacks and related comorbidities.
Authors and Affiliations
Ravikant Jain, Nikhil Jain, Nihit Mantri
Keywords
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