Effect of withholding phenobarbitone maintenance therapy in neurodevelopmental outcome at 1 year of age in neonatal seizures
Journal Title: IP International Journal of Medical Paediatrics and Oncology - Year 2017, Vol 3, Issue 4
Abstract
Objective: To investigate effect of withholding phenobarbitone maintenance therapy in neurodevelopmental outcome at 1 year of age in neonatal seizures Materials and Methods: Design: This study was conducted to evaluate neurodevelopmental assessment at 1 year of age of babies enrolled in a previous interventional randomized controlled trial done at our NICU. Participants: 152 late preterm and term infants were allocated to phenobarbitone maintenance group (n=77) or placebo group (n=75). We enrolled late preterm and term infants with seizures after receiving loading dose of phenobarbitone. Both phenobarbitone maintenance and placebo group participants were followed at 1 year of age and neurodevelopmental screening was done by Denver II. Outcome measure(s): Outcome was abnormal examination through Denver II at follow up at 12-18 months and to measure seizure recurrence & rehospitalisation in both groups. Results: 152 babies were enrolled in this study. Outcome data was available for 92 (85.2 %) of the 108 alive infants at 1 year of age. The baseline characteristics of the babies in 2 groups were comparable. Abnormal examination as per Denver II occurred in 19/43 (44.19%) subjects in placebo group and 21/49 (42.86%) in phenobarbitone group. Seizure recurrence and rehospitalisation till 1 year of age were comparable in both groups. Conclusion: This study concluded that withholding phenobarbitone maintenance immediately after loading dose of phenobarbitone in neonatal seizures does not result in worsening of neurodevelopmental outcome, or mortality and recurrence of seizures till 1 year of age.
Authors and Affiliations
Pankaj kr. Ravi, Vikas Agarwal, Priyanka Gupta, Amit Upadhyay
Keywords
Related Articles
- EP ID EP300978
- DOI 10.18231/2455-6793.2017.0035
- Views 103
- Downloads 0
Oral Sildenafil for pulmonary hypertension associated with congenital heart disease in children – single center, prospective, pilot study
Objective: To study the efficacy of oral sildenafil for pulmonary hypertension (PH) in children associated with congenital heart disease. Methods: This was a prospective observational study carried at Neonatal and Pediat...
Morbidities of ELBW babies affecting their outcome: An observational study
Introduction: There are significant risk factors like birth asphyxia, HMD, sepsis, pulmonary hemorrhage, IVH etc. predicting survival of the ELBW neonates and is associated with increased mortality. Expectant parents of...
Role of 2D echo in neonates with perinatal asphyxia and its correlation with cardiac troponin T levels and creatine kinase MB
Objectives: To evaluate myocardial function in neonates with perinatal asphyxia by 2D Echo and cardiac Troponin T levels and creatine kinase MB. Methods: 30 term babies with perinatal asphyxia were selected as cases. The...
Dosimetric analysis of normal tissue toxicity in 3D conformal radiotherapy planning with fused PET-CT imaging in non-small cell lung carcinoma
Introduction The prime modality for inoperable NSCLC is radiation therapy and or chemoradiation and better results can be achieved by a higher dose of radiation However dose escalation is difficult due to presence of cri...
Prevalence and causation of anemia among pediatric age group patients
Background: Anemia prevalence in all age group children continues to remain in most parts of India and Asia. One of the most common factors in causation of anaemia is malnutrition; iron deficiency making the most of it....