Effectiveness and Toxicity Risk of Intravenous Aminophylline in Exacerbation Asthma Treatment
Journal Title: Indonesian Journal of Clinical Pharmacy - Year 2018, Vol 7, Issue 2
Abstract
Asthma is a chronic inflammatory disease in the respiratory tract that has a considerable global prevalence. The worsening of asthma is an asthma attack that causes asthma symptoms to increase and decreased lung function progressively. One of the most commonly used asthma medications in Indonesia is intravenous aminophylline. Aminophylline is a drug with a narrow range of therapies that is at risk of causing drug toxicity, but the comparative data on the efficacy and safety benefits of the drug are inadequate. This study aimed to determine the effectiveness of aminophylline intravenously in the early treatment of asthma attacks in the form of improvements in asthma symptoms and toxicity events related to the symptoms that appear and blood theophylline levels in a hospital in Surabaya, Indonesia. This study used a pre-experimental method which was carried out from 2014 to 2016. A total of twenty seven patients were involved in the study. The therapy given was aminophylline intravenously for one hour. The sampling method used was consecutive sampling with descriptive analysis technique. All subjects showed improved symptoms of asthma attacks with intravenous aminophylline therapy for one hour, and none had toxicity due to theophylline levels in the blood below the therapeutic range. Aminophylline is still effective in reducing symptoms in asthma attacks and does not indicate the risk of toxicity.
Authors and Affiliations
Amelia Lorensia, Zullies Ikawati, Tri M. Andayani, Rivan V. Suryadinata, Khaula A. A. Hantoro
Keywords
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- EP ID EP370264
- DOI 10.15416/ijcp.2018.7.2.78
- Views 95
- Downloads 0
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