Effects of 2-chloroadenosine on cortical epileptic afterdischarges in immature rats.
Journal Title: Pharmacological Reports - Year 2010, Vol 62, Issue 1
Abstract
Adenosine may represent an endogenous anticonvulsant in the brain. This study focused on the possible anticonvulsant action of an adenosine agonist, 2-chloroadenosine, against cortical epileptic afterdischarges (ADs) in immature rats. Three age groups of rat pups with implanted electrodes were studied: 12-, 18- and 25-days-old. The compound, 2-chloroadenosine, was injected after the first successful stimulation at doses of 1, 4 or 10 mg/kg intraperitoneally, and stimulation at the same intensity was repeated three more times. Movements directly elicited by stimulation, as well as clonic seizures accompanying electroencephalography (EEG) ADs, were markedly suppressed in only the 18-day-old animals. The effects in the 12- and especially the 25-day-old rats were moderate. The duration of the ADs decreased in all three age groups with 2-chloroadenosine treatment, and the shortest AD duration was seen in the treated, 12-day-old rats. The AD suppression also lasted longer in this age group than it did in the older animals. After a brief suppression of the second AD, the treated, 25-day-old group exhibited a significant AD rebound during the third and fourth stimulations. Taken together, our data show that 2-chloroadenosine exhibits an anticonvulsant effect that is dose- and age-dependent.
Authors and Affiliations
Marie Pometlová, Hana Kubová, Pavel Mareš
Keywords
Related Articles
- EP ID EP139487
- DOI -
- Views 116
- Downloads 0
Update on the management of polycystic ovary syndrome.
Polycystic ovary syndrome (PCOS) is a common endocrine disorder that affects 5% to 10% of women in reproductive age. It is the most simply defined as the association of hyperandrogenism (diagnosed clinically and/or bioch...
Prostacyclin, but not nitric oxide, is the major mediator of acetylcholine-induced vasodilatation in the isolated mouse heart.
In many species, acetylcholine (Ach) induces coronary vasodilatation via endothelium-derived nitric oxide (NO). The aim of the present study was to examine if this rule pertains also to the coronary circulation of the mo...
Acute doxorubicin nephrotoxicity in rats with malignant neoplasm can be successfully treated with fullerenol C(60)(OH)(24) via suppression of oxidative stress.
Oxidative stress has an important role in the pathogenesis of doxorubicin (DOX)-induced nephrotoxicity. The aim of this study was to investigate the nephroprotective effects of fullerenol (FLR), an antioxidant agent, on...
Effects of two isomers of DDT and their metabolite DDE on CYP1A1 and AhR function in human placental cells.
The aim of this study was to investigate the actions of two isomers of DDT (p,p'-DDT, o,p'-DDT) and DDE (p,p'-DDE, o,p'-DDE) on the human placenta. We studied the effects of DDT and its metabolite DDE on CYP1A1 activity...
Neurochemical and behavioral effects of 8-OH-DPAT following exposure to restraint stress in rats.
8-Hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), a selective 5-hydroxytryptamine 1A (serotonin; 5-HT(1A)) agonist was used to evaluate the role of somatodendritic and/or postsynaptic 5-HT(1A) receptors following expos...